Acquired information is stabilized into long-term memory through a process known as consolidation. Though, after consolidation, when stored information is retrieved they can be again susceptible, allowing modification, updating and strengthening and to be re-stabilized they need a new process referred to as memory reconsolidation. However, the molecular mechanisms of recognition memory consolidation and reconsolidation are not fully understood. Also, considering that the study of the link between synaptic proteins is key to understanding of memory processes, we investigated, in male Wistar rats, molecular mechanisms in the hippocampus involved on object recognition memory (ORM) consolidation and reconsolidation. We verified that the blockade of AMPA receptors (AMPAr) and L-VDCCs calcium channels impaired ORM consolidation and reconsolidation when administered into CA1 immediately after sample phase or reactivation phase and that these impairments were blocked by the administration of AMPAr agonist and of neurotrophin BDNF. Also, the blockade of CaMKII impaired ORM consolidation when administered 3 h after sample phase but had no effect on ORM reconsolidation and its effect was blocked by the administration of BDNF, but not of AMPAr agonist. So, this study provides new evidence of the molecular mechanisms involved on the consolidation and reconsolidation of ORM, demonstrating that AMPAr and L-VDCCs are necessary for the consolidation and reconsolidation of ORM while CaMKII is necessary only for the consolidation and also that there is a link between BDNF and AMPAr, L-VDCCs and CaMKII as well as a link between AMPAr and L-VDCCs on ORM consolidation and reconsolidation.

中文翻译：

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海马的分子机制涉及对象识别记忆的巩固和再巩固。

通过称为合并的过程，将获取的信息稳定到长期存储器中。尽管在合并之后，当检索到存储的信息时，它们可能再次受到影响，从而允许进行修改，更新和加强，并且要重新稳定，它们需要一个称为内存重新合并的新过程。但是，识别记忆巩固和再巩固的分子机制尚未完全了解。此外，考虑到对突触蛋白之间的联系的研究是了解记忆过程的关键，我们在雄性Wistar大鼠中调查了海马中涉及对象识别记忆（ORM）整合和再整合的分子机制。我们验证了在样品阶段或再活化阶段后立即将CAPA给药后，AMPA受体（AMPAr）和L-VDCCs钙通道的阻滞会损害ORM巩固和再巩固，并且通过AMPAr激动剂和神经营养蛋白BDNF的给药可以阻断这些损伤。同样，在样品期后3 h给予CaMKII的阻断会损害ORM的整合，但对ORM的再整合没有影响，而BDNF的阻断作用却被AMPAr激动剂的阻断。因此，本研究提供了有关ORM固结和再固结的分子机制的新证据，