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Ketoprofen affects swimming behavior and impairs physiological endpoints of Daphnia magna.
Science of the Total Environment ( IF 8.2 ) Pub Date : 2020-04-08 , DOI: 10.1016/j.scitotenv.2020.138312
Adam Bownik 1 , Magdalena Jasieczek 1 , Ewelina Kosztowny 1
Affiliation  

Ketoprofen (KET) is a nonsteroidal anti-inflammatory and analgesic drug commonly used in human and veterinary medicine. This compound is detected in aquatic reservoirs however, little is known about its influence on cladocerans. Therefore, the aim of our study was to determine the influence of KET at concentrations of 0.005 mg/L, 0.05 mg/L, 0.5 mg/L, 5 mg/L and 50 mg/L on behavioral (swimming speed, hopping frequency) and physiological endpoints (heart rate, thoracic limb activity, mandible movements) of Daphnia magna after 24 h and 48 h exposure. The study showed that swimming speed frequency was decreased after 24 h and 48 h at all the concentrations used in the experiment. Hopping frequency was also inhibited, however the lowest amount of the drug induced transient increase of the parameter after 24 h and its subsequent decrease to the control level after 48 h. Although after 24 h of the exposure physiological parameters: heart rate, thoracic limb activity and mandible movements showed slightly lower sensitivity to KET than the behavioral endpoints: were found to be inhibited after 48 h. The results revealed that both behavioral and physiological endpoints of daphnids responded to KET also at the environmental level, therefore in natural conditions this drug should be considered as a hazardous toxicant to crustaceans.

中文翻译:

酮洛芬会影响游泳行为,并损害水蚤的生理终点。

酮洛芬(KET)是一种非甾体类抗炎镇痛药,常用于人类和兽医学。在水生水库中检测到该化合物,但对其对锁角藻的影响知之甚少。因此,我们的研究目的是确定浓度为0.005 mg / L,0.05 mg / L,0.5 mg / L,5 mg / L和50 mg / L的KET对行为(游泳速度,跳跃频率)的影响暴露24 h和48 h后的大型蚤(Daphnia magna)的生理和生理指标(心率,胸肢活动,下颌骨运动)。研究表明,在实验中使用的所有浓度下,游泳速度频率在24小时和48小时后都会降低。跳频也受到抑制,但是,在24小时后,药物引起的参数瞬时增加最低,而在48小时后,其下降至对照水平最低。尽管在暴露24小时后,生理参数:心率,胸肢活动和下颌骨运动对KET的敏感性比行为终点略低:发现在48小时后被抑制。结果表明,在环境水平上,蚤的行为和生理终点均对KET产生反应,因此在自然条件下,该药物应被视为对甲壳类动物有害的毒物。被发现在48小时后被抑制。结果表明,在环境水平上,蚤的行为和生理终点均对KET产生反应,因此在自然条件下,该药物应被视为对甲壳类动物有害的毒物。被发现在48小时后被抑制。结果表明,在环境水平上,蚤的行为和生理终点均对KET产生反应,因此在自然条件下,该药物应被视为对甲壳类动物有害的毒物。
更新日期:2020-04-08
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