An aneurysm is a life‐threatening vascular disease. Embolization with shape memory (SM) hydrogel coils is promising for the treatment of the intractable aneurysms. However, single temperature‐triggered SM is softened in a catheter, and delivery of multiple coils is required, which may clog the catheter and complicate operation procedure. Here, a radiopaque temperature/pH dual responsive shape memory hydrogel with self‐tuned stiffness is fabricated by copolymerizing acrylonitrile (AN, dipole–dipole interaction monomer), N ‐acryloyl 2‐glycine (ACG, pH‐sensitive H‐bonding monomer), and polyethylene glycol diacrylate. Under slightly acidic conditions without eliciting cytotoxicity, additional supramolecular PACG hydrogen bonds combined with cyano dipole–dipole pairings contribute to the body temperature‐triggered SM effect with an unprecedented high 430 MPa (10 °C) and 16 MPa (37 °C) Young's modulus. A carotid aneurysm is created in a dog to test the embolization of this SM hydrogel. At 37 °C, the hydrogel's high stiffness ensures its smooth delivery through a catheter. After being transported into the aneurysm sac, secondary swelling occurs concurrent with appropriate decrease of stiffness upon contacting neutral blood, thus enhancing the packing density and reducing recanalization rate and delivery times. This stiffness adaptive SM hydrogel holds its great potential as permanent embolic agents for treating a variety of aneurysms.

中文翻译：

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用于动脉瘤栓塞的刚度自调整形状记忆水凝胶

动脉瘤是威胁生命的血管疾病。形状记忆（SM）水凝胶线圈的栓塞术有望用于顽固性动脉瘤的治疗。但是，单个温度触发的SM在导管中被软化，并且需要传送多个线圈，这可能会堵塞导管并使操作过程复杂化。在此，通过丙烯腈（AN，偶极-偶极相互作用单体），N的共聚制备具有自调整刚度的不透射线温度/ pH双响应形状记忆水凝胶丙烯酰基2-甘氨酸（ACG，pH敏感的H键单体）和聚乙二醇二丙烯酸酯。在弱酸性条件下，不会引起细胞毒性，额外的超分子PACG氢键与氰基偶极-偶极对组合可促进体温触发的SM效应，具有前所未有的高430 MPa（10°C）和16 MPa（37°C）杨氏模量。在狗中产生一个颈动脉瘤，以测试这种SM水凝胶的栓塞作用。在37°C时，水凝胶的高刚度可确保其通过导管的顺利输送。在被输送到动脉瘤囊中后，发生二次肿胀，同时接触中性血液时刚度适当降低，从而提高了包装密度并缩短了再通率和递送时间。