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Green Light‐Based Photobiomodulation with an Implantable and Biodegradable Fiber for Bone Regeneration
Small Methods ( IF 10.7 ) Pub Date : 2020-04-07 , DOI: 10.1002/smtd.201900879
Yuxi Jiang 1, 2, 3, 4 , Wei Qi 1, 3, 4, 5 , Qianyi Zhang 6 , Hao Liu 1, 7 , Jianyun Zhang 1, 8 , Ning Du 1, 7 , Roya Nazempour 9 , Yuanzhe Su 9 , Ruxing Fu 6 , Kaiyuan Zhang 9 , Peijun Lyu 1, 2, 3, 4 , Fan Dong 1, 2, 3, 4 , Lan Yin 6 , Xing Sheng 9, 10 , Yuguang Wang 1, 2, 3, 4
Affiliation  

Photobiomodulation (PBM) has recently started to gain popularity in clinical therapeutics. Visible light, in particular, plays a critical role in osteogenesis modulation. However, the limited penetration depth of visible light in biological tissues has constrained the application of this technology in vivo. Herein a green light‐based PBM technique with implantable and biodegradable poly(L‐lactic acid) & poly(L‐actic‐co‐glycolic acid) optical fibers to achieve accelerated bone regeneration is explored. Facilitated with experimental characterizations as well as numerical simulations, optical and thermal behaviors of fibers operated in the biological environment are understood. The optical regulation of bone regeneration is systematically studied both in vitro and in vivo. Under green light irradiation, biochemical activities of bone marrow‐derived mesenchymal stem cells and their expression of osteogenic‐related factors are significantly elevated. By introducing green light into defective bone structures via fibers in a rodent model, the process of bone regeneration and repair is accelerated. Furthermore, fibers exhibit ideal biocompatibility with both cultured cells and living tissues and undergo complete degradation in vivo after ≈1 month. Assisted with degradable optical materials and devices, such as photobiomodulation technique provides a promising solution to tissue regeneration in various biomedical applications.

中文翻译:

可植入和可降解纤维的绿光基光生物调节,可进行骨再生。

光生物调节(PBM)最近已开始在临床治疗中获得普及。可见光尤其在成骨调节中起关键作用。然而,可见光在生物组织中的有限穿透深度限制了该技术在体内的应用。本文探讨了一种基于绿色光的PBM技术,该技术采用可植入和可生物降解的聚L-乳酸和聚L-乳酸-乙醇酸光纤来加速骨骼再生。通过实验表征和数值模拟,可以理解在生物环境中操作的纤维的光学和热行为。在体外和体内系统地研究骨再生的光学调节。在绿光照射下 骨髓间充质干细胞的生化活性及其成骨相关因子的表达显着提高。通过在啮齿动物模型中通过纤维将绿色光引入缺陷的骨骼结构中,可以加速骨骼的再生和修复过程。此外,纤维与培养的细胞和活组织均表现出理想的生物相容性,并且在约1个月后会在体内完全降解。借助可降解的光学材料和设备,例如光生物调制技术,可以为各种生物医学应用中的组织再生提供有希望的解决方案。骨骼再生和修复的过程加快了。此外,纤维与培养的细胞和活组织均表现出理想的生物相容性,并且在约1个月后会在体内完全降解。借助可降解的光学材料和设备,例如光生物调制技术,可以为各种生物医学应用中的组织再生提供有希望的解决方案。骨骼再生和修复的过程加快了。此外,纤维与培养的细胞和活组织均表现出理想的生物相容性,并且在约1个月后会在体内完全降解。借助可降解的光学材料和设备,例如光生物调制技术,可以为各种生物医学应用中的组织再生提供有希望的解决方案。
更新日期:2020-04-07
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