Articular cartilage has no innate ability to repair when damaged due to its avascular nature, and lacks a rich source of progenitor cells and growth factors required for regeneration.¹ Although a number of therapeutic approaches have been proposed to treat osteochondral defects, none to date has been proven to ensure a sustained regeneration. Current clinical approaches have shown significant limitations and drawbacks, and offer mostly temporary reduction in the symptoms without any repair of the damaged tissues.²

中文翻译：

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用于骨软骨再生的胶原-羟基磷灰石仿生梯度支架

关节软骨由于其无血管性质而在受损时没有先天修复能力，并且缺乏再生所需的丰富祖细胞和生长因子来源。¹尽管已经提出了许多治疗方法来治疗骨软骨缺损，但迄今为止没有一种方法被证明可以确保持续再生。当前的临床方法已显示出明显的局限性和缺点，并且主要是暂时减轻症状，而不需要对受损组织进行任何修复。²