Thanks to its pharmaceutical properties, the Schiff group of isatin has recently had a wide range of uses. In this study, seven new Schiff bases of isatin and its derivatives were prepared from thiocarbohydrazide, isatin and substituted aldehydes in the presence of ethanol under reflux. The chemical structures of the products were confirmed by ¹H NMR, ¹³C NMR, IR and elemental analysis. The in vitro antioxidant features of all the compounds were evaluated by 1,1-diphenyl-2-picrylhydrazyl free radical scavenging method. The antioxidant effect was evaluated separately in two different stages: monosubstituted products synthesized with aldehyde groups and disubstituted products bound with isatin group. Accordingly, the compounds 3 and 4 showed the highest antioxidant activity and the isatin group suppressed the antioxidant effect of the disubstituted Schiff bases products.

凭借其药用特性，希夫（Schiff）的Isatin组最近得到了广泛的应用。在这项研究中，在乙醇存在下，在回流条件下，由硫代碳酰肼，Isatin和取代的醛制备了七个新的Isatin Schiff碱及其衍生物。产物的化学结构通过¹ H NMR，¹³ C NMR，IR和元素分析确认。通过1，1-二苯基-2-吡啶并肼基自由基清除方法评价了所有化合物的体外抗氧化性能。在两个不同阶段分别评估了抗氧化效果：与醛基合成的单取代产物和与靛红基团结合的双取代产物。因此，化合物3和4 显示出最高的抗氧化活性，而芥子基抑制了双取代席夫碱产物的抗氧化作用。