Abstract

An efficient, green and facile route for the one-pot four-component synthesis of pyranopyrazole derivatives through the condensation of the aromatic aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate using baker’s yeast as biocatalyst is presented. The important aspects of the present methodology are the use of an environmentally friendly catalyst, high yield of products and mild reaction conditions, i.e. at neutral pH and ambient temperature.

Graphic abstract

中文翻译：

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在非水介质中通过生物催化一锅Knoevenagel缩合-Michael型加成-杂环级联反应绿色合成吡喃并吡唑

摘要

提出了一种高效，绿色，简便的路线，以贝克酵母作为生物催化剂，通过芳香醛，乙酰乙酸乙酯，丙二腈和水合肼的缩合，一锅四组分合成吡喃并吡唑衍生物。本方法学的重要方面是使用环境友好的催化剂，高产率的产物和温和的反应条件，即在中性pH和环境温度下。

图形摘要