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A Rab prenyl membrane-anchor allows effector recognition to be regulated by guanine nucleotide [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-04-07
Miriam Lee, William Wickner, Hongki Song

Membrane fusion is catalyzed by conserved proteins R, Qa, Qb, and Qc SNAREs, which form tetrameric RQaQbQc complexes between membranes; SNARE chaperones of the SM, Sec17/αSNAP, and Sec18/NSF families; Rab-GTPases (Rabs); and Rab effectors. Rabs are anchored to membranes by C-terminal prenyl groups, but can also function when anchored by...

中文翻译:

Rab异戊二烯膜锚可以通过鸟嘌呤核苷酸调节效应子的识别[生物化学]

保守的蛋白R,Qa,Qb和Qc SNARE催化膜融合,它们在膜之间形成四聚体RQaQbQc络合物。SM,Sec17 /αSNAP和Sec18 / NSF家族的SNARE分子伴侣;Rab-GTPases(Rabs); 和Rab效应器。刺通过C末端异戊二烯基团锚定在膜上,但在通过...固定时也可以起作用。
更新日期:2020-04-08
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