Methionine metabolism is critical for the maintenance of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) pluripotency. However, little is known about the regulation of the methionine cycle to sustain ESC pluripotency. Here, we show that adenosylhomocysteinase (AHCY), an important enzyme in the methionine cycle, is critical for...

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O-GlcNAcylation调节蛋氨酸循环以促进干细胞的多能性[生物化学]

蛋氨酸代谢对于维持胚胎干细胞（ESC）和诱导多能干细胞（iPSCs）多能性至关重要。然而，关于维持蛋氨酸多能性的蛋氨酸循环的调控知之甚少。在这里，我们表明，腺苷同型半胱氨酸酶（AHCY）是蛋氨酸循环中的重要酶，对于...至关重要。