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Broad and thematic remodeling of the surfaceome and glycoproteome on isogenic cells transformed with driving proliferative oncogenes [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-04-07
Kevin K. Leung, Gary M. Wilson, Lisa L. Kirkemo, Nicholas M. Riley, Joshua J. Coon, James A. Wells

The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is dramatically remodeled in an isogenic breast epithelial cell line stably expressing any...

中文翻译:

驱动增生癌基因转化的同基因细胞上的表面组和糖蛋白组的广泛和主题重塑[生物化学]

细胞表面蛋白质组,表面组,是用于接合正常细胞和癌细胞中细胞外空间的界面。在这里,我们应用N-连接糖蛋白的定量蛋白质组学,揭示在稳定表达任何信息的等基因乳腺上皮细胞系中,约700种表面蛋白的集合是如何显着重塑的。
更新日期:2020-04-08
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