Protein–lipid interactions are a key element of the function of many integral membrane proteins. These potential interactions should be considered alongside the complexity and diversity of membrane lipid composition. Inward rectifier potassium channel (Kir) Kir2.2 has multiple interactions with plasma membrane lipids: Phosphatidylinositol (4, 5)-bisphosphate (PIP2) activates the channel; a...

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定义多种脂质物质如何与内向整流钾（Kir2）通道相互作用[生物物理学和计算生物学]

蛋白质-脂质相互作用是许多整合膜蛋白功能的关键要素。这些潜在的相互作用应与膜脂质成分的复杂性和多样性一起考虑。内向整流钾通道（Kir）Kir2.2与质膜脂质具有多种相互作用：磷脂酰肌醇（4，5）-双磷酸酯（PIP2）激活该通道。一种...