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Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans [Chemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2020-04-07
Diane Dayoung Park, Chatchai Phoomak, Gege Xu, Laura P. Olney, Khiem A. Tran, Simon S. Park, Nathan E. Haigh, Guillaume Luxardi, Worachart Lert-itthiporn, Michiko Shimoda, Qiongyu Li, Nobuyuki Matoba, Fernando Fierro, Sopit Wongkham, Emanual Maverakis, Carlito B. Lebrilla

Membrane-bound oligosaccharides form the interfacial boundary between the cell and its environment, mediating processes such as adhesion and signaling. These structures can undergo dynamic changes in composition and expression based on cell type, external stimuli, and genetic factors. Glycosylation, therefore, is a promising target of therapeutic interventions for presently incurable...

中文翻译:

扩展的高甘露糖聚糖可促进胆管癌的转移[化学]

膜结合寡糖形成细胞与其环境之间的界面边界,介导粘附和信号传导等过程。这些结构可能会根据细胞类型,外部刺激和遗传因素而在组成和表达上发生动态变化。因此,糖基化是目前无法治愈的治疗性干预的有希望的目标。
更新日期:2020-04-08
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