Gene regulation in embryonic stem cells (ESCs) has been extensively studied at the epigenetic-transcriptional level, but not at the posttranscriptional level. Pumilio (Pum) proteins are among the few known translational regulators required for stem-cell maintenance in invertebrates and plants. Here we report the essential function of two murine Pum proteins,...

中文翻译：

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Pumilio蛋白利用独特的调节机制来实现多能性和胚胎发生所需的互补功能[发育生物学]

胚胎干细胞（ESCs）中的基因调控已在表观遗传转录水平上进行了广泛研究，但在转录后水平上没有进行研究。Pumilio（Pum）蛋白是无脊椎动物和植物中干细胞维持所需的少数几种已知的翻译调节剂。在这里，我们报告两种鼠Pum蛋白的基本功能，...