Methamphetamine (METH) abuse has become a global problem, and new strategies for rapid and sensitive detection of METH are in urgent need. Herein, a novel technique is developed for highly sensitive detection of METH in solution with a broad concentration range by the assembly of AIE luminogen of tetrakis(4-(pyridin-4-yl)phenyl)ethene (TPPE) and cucurbit[7]uril (CB[7]). The ¹H NMR and isothermal titration calorimetry (ITC) characterizations confirm that TPPE and CB[7] are self-assembled in a ratio of 1:4. While, the interaction of CB[7] with METH exhibits a binding ratio of 1:1 and stronger binding ability than with TPPE. Based on the competitive binding affinity, CB[7]⊃TPPE could be used as a chemosensor to detect METH in solution, which exhibits remarkable advantages such as rapid response, high sensitivity and low limit of detection (LOD). When the concentration of METH solution is larger than 40 μM, the enhancement of fluorescence intensity and change of fluorescent colour could be directly observed upon UV irradiation. When the METH solution concentration is higher than 10 μM, we can use our fabricated test strips to rapidly and visibly detect. If above detections do not work, we can measure the photoluminescence (PL) spectra of the sensing system, which shows a LOD as low as 0.43 μM. This unique CB[7]⊃TPPE based chemosensor is potentially applicable in real-time and visual detection of METH in solution and provides a powerful platform for preventing chemical solvent transport.

甲基苯丙胺（METH）的滥用已成为一个全球性的问题，迫切需要能够快速灵敏地检测出METH的新策略。在此，通过四（4-（吡啶-4-基）苯基）乙烯（TPPE）和葫芦[7]尿素的AIE发光剂的组装，开发了一种新技术，可用于高灵敏度检测宽浓度范围的溶液中的甲乙二胺。 （CB [7]）。在¹1 H NMR和等温滴定热法（ITC）表征证实TPPE和CB [7]以1：4的比例自组装。而CB [7]与METH的相互作用比TPPE具有1：1的结合率和更强的结合能力。基于竞争结合亲和力，CB [7]⊃TPPE可作为化学传感器检测溶液中的甲基苯丙氨酸，具有响应速度快，灵敏度高和检测限低的显着优势。当METH溶液的浓度大于40μM时，在UV照射下可以直接观察到荧光强度的增强和荧光颜色的变化。当METH溶液浓度高于10μM时，我们可以使用制造的测试条进行快速可见的检测。如果上述检测无效，我们可以测量传感系统的光致发光（PL）光谱，其LOD低至0.43μM。这种独特的基于CB [7] PETPPE的化学传感器可潜在地应用于溶液中METH的实时和视觉检测，并为防止化学溶剂的运输提供了强大的平台。