Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?,Journal of Photochemistry and Photobiology B: Biology

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Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?
Journal of Photochemistry and Photobiology B: Biology ( IF 3.9 ) Pub Date : 2020-04-07 , DOI: 10.1016/j.jphotobiol.2020.111877
Kenia Mendes Rodrigues Castro ₁ , Rodrigo Leal de Paiva Carvalho ₂ , Geraldo Marco Rosa Junior ₃ , Beatriz Antoniassi Tavares ₃ , Luis Henrique Simionato ₃ , Carlos Henrique Fachin Bortoluci ₃ , Claudio Alberto Tellez Soto ₁ , Cleber Ferraresi ₁

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Photobiomodulation therapy (PBMT) has many effects on the energy metabolism of musculoskeletal tissue, such as increased glycogen and adenosine triphosphate synthesis. In addition, these effects may be due to a systemic blood glucose control. Twenty-four Wistar rats were randomly and equally allocated into four groups: sham, PBMT 10 J/cm2, PBMT 30 J/cm2 and PBMT 60 J/cm2. The animals were fasting for 6 h for blood glucose evaluations during pre-irradiation period, 1 h, 3 h and 6 h after PBMT. Muscle glycogen synthesis was measured 24 h after PBMT. This PBMT used a cluster of 69 LEDs (light-emitting diodes) with 35 red (630 ± 10 nm) and 34 infrared (850 ± 20 nm); 114 mW/cm2 for 90s (10 J/cm2), 270 s (30 J/cm2), 540 s (60 J/cm2) applied on large muscle areas (back and hind legs) of the animals. The 10 J/cm2 group showed lower blood glucose levels and glucose variability over 6 h (5.92 mg/dL) compared to the sham (13.03 mg/dL), 30 J/cm2 (7.77 mg/dL) and 60 J/cm2 (9.07 mg/dL) groups. The PBMT groups had the greatest increase in muscle glycogen (10 J/cm2 > 60 J/cm2 > 30 J/cm2 > sham), characterizing a triphasic dose-response of PBMT. There was a strong negative correlation between blood glucose variability over 6 h and muscle glycogen concentration for 10 J/cm2 group (r = -0.94; p < .001) followed by 30 J/cm2 group (r = -0.84; p < .001) and 60 J/cm2 group(r = -0.73; p < .006). These results suggest that PBMT can play a very important role in the control of blood glucose levels, and its possible mechanism of action is the induction of greater muscle glycogen synthesis independently of physical exercise.

中文翻译：

光生物调节疗法（PBMT）可以控制血糖水平并改变肌肉糖原合成吗？

光生物调节疗法（PBMT）对肌肉骨骼组织的能量代谢有许多影响，例如糖原的增加和三磷酸腺苷的合成。另外，这些作用可能是由于全身血糖控制所致。将二十四只Wistar大鼠随机分为四组：假手术，PBMT 10 J / cm2，PBMT 30 J / cm2和PBMT 60 J / cm2。在放疗前，PBMT后1小时，3小时和6小时，动物禁食6小时进行血糖评估。在PBMT后24小时测量肌肉糖原合成。该PBMT使用了由35个红色（630±10 nm）和34个红外（850±20 nm）的69个LED（发光二极管）组成的集群；在动物的大块肌肉区域（后腿和后腿）施加90秒钟（10 J / cm2），270秒钟（30 J / cm2），540秒钟（60 J / cm2）的114 mW / cm2。与假手术（13.03 mg / dL），30 J / cm2（7.77 mg / dL）和60 J / cm2（10 J / cm2）相比，在6小时内（5.92 mg / dL）的血糖水平和葡萄糖变异性更低。 9.07 mg / dL）组。PBMT组的肌肉糖原增加最大（10 J / cm2> 60 J / cm2> 30 J / cm2>假手术），表现出PBMT的三重剂量反应。10 J / cm2组的6 h血糖变异性与肌肉糖原浓度之间存在强烈的负相关性（r = -0.94; p <.001），随后是30 J / cm2组（r = -0.84; p <。 001）和60 J / cm2组（r = -0.73; p <.006）。这些结果表明，PBMT可以在控制血糖水平中发挥非常重要的作用，其可能的作用机制是独立于体育锻炼诱导更大的肌肉糖原合成。

更新日期：2020-04-07

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