Some Rab GTPases, after activation by GDP to GTP exchange, are phosphorylated by the LRRK2 kinase implicated in Parkinson’s disease. In the current issue of Structure, Waschbüsch et al. (2020) investigate the structural basis for recognition of active phospho-Rab GTPases by the RH2 domain of the effector protein RILPL2.

中文翻译：

---

X为在睫毛发生和帕金森氏病中磷酸化Rab GTPase识别的磷酸盐加盖。

一些Rab GTPases在被GDP激活为GTP交换后，被与帕金森氏病有关的LRRK2激酶磷酸化。在当前的结构期刊中，Waschbüsch等人。（2020）研究效应蛋白RILPL2的RH2结构域识别活性磷酸化Rab GTPases的结构基础。