Lactate accumulation in tumors—a hallmark of the Warburg effect—has recently been shown to regulate cancer cell metabolism and survival through autocrine activation of GPR81. Now, Brown et al. (2020) demonstrate that lactate surprisingly also controls immune evasion through paracrine activation of GPR81 on stromal dendritic cells.

中文翻译：

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华宝为何运作：乳酸通过GPR81控制免疫逃逸

最近显示，乳酸在肿瘤中的蓄积是Warburg效应的标志，它通过GPR81的自分泌激活来调节癌细胞的代谢和存活。现在，布朗等。（2020）证明乳酸令人惊讶地还通过间质树突状细胞上的旁分泌激活GPR81来控制免疫逃逸。