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Current situation of clinical islet transplantation from allogeneic toward xenogeneic.
Journal of Diabetes ( IF 4.5 ) Pub Date : 2020-04-20 , DOI: 10.1111/1753-0407.13041
Shinichi Matsumoto 1 , Masayuki Shimoda 1
Affiliation  

Currently, type 1 diabetes requires lifelong insulin injection and careful blood glucose control to prevent secondary complications, but islet transplantation could make a type 1 diabetic patient insulin independent. On the other hand, islet transplantation needs human donors and donor shortage is the most serious issue. To alleviate the donor shortage, non‐heart‐beating and living donors were used; in addition, the efficacy of islet isolation and transplantation has been improved. However, the donor shortage issue will not be solved as long as human donors are the only source.

中文翻译:

临床胰岛移植从同种异体到异种的现状。

目前,1 型糖尿病需要终生注射胰岛素和仔细控制血糖以防止继发性并发症,但胰岛移植可以使 1 型糖尿病患者独立于胰岛素。另一方面,胰岛移植需要人体供体,供体短缺是最严重的问题。为缓解供体短缺,使用无心跳和活体供体;此外,胰岛分离移植的疗效也有所提高。然而,只要人类捐赠者是唯一的来源,捐赠者短缺的问题就不会得到解决。
更新日期:2020-04-20
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