Virtual screening, synthesis, and bioactivity evaluation for the discovery of β-N-acetyl-D-hexosaminidase inhibitors.,Pest Management Science

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Virtual screening, synthesis, and bioactivity evaluation for the discovery of β-N-acetyl-D-hexosaminidase inhibitors.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-04-05 , DOI: 10.1002/ps.5852
Yawen Dong ₁ , Song Hu ₁ , Xiao Zhao ₁ , Qi He ₁ , Qing Yang ₂ , Li Zhang ₁

Affiliation

Molting is an essential insect developmental process, in which a variety of enzymes are involved. The inhibition of these enzymes effect normal insect growth and development and may even cause death. OfHex1, one of the β‐N‐acetyl‐D‐hexosaminidases, is a key enzyme involved in the molting process of the Asian corn borer (Ostrinia furnacalis), and is deemed a potential insecticidal target.

中文翻译：

虚拟筛选，合成和生物活性评估，用于发现β-N-乙酰基-D-己糖胺酶抑制剂。

蜕皮是必不可少的昆虫发育过程，其中涉及多种酶。这些酶的抑制作用会影响昆虫的正常生长和发育，甚至可能导致死亡。的Hex1，所述β-之一Ñ乙酰基d己糖胺酶，是参与亚洲玉米螟的蜕皮过程中的关键酶（玉米螟），并且被认为是潜在的目标杀虫。

更新日期：2020-04-05

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