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Virtual screening, synthesis, and bioactivity evaluation for the discovery of β-N-acetyl-D-hexosaminidase inhibitors.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-04-05 , DOI: 10.1002/ps.5852
Yawen Dong 1 , Song Hu 1 , Xiao Zhao 1 , Qi He 1 , Qing Yang 2 , Li Zhang 1
Affiliation  

Molting is an essential insect developmental process, in which a variety of enzymes are involved. The inhibition of these enzymes effect normal insect growth and development and may even cause death. OfHex1, one of the β‐N‐acetyl‐D‐hexosaminidases, is a key enzyme involved in the molting process of the Asian corn borer (Ostrinia furnacalis), and is deemed a potential insecticidal target.

中文翻译:

虚拟筛选,合成和生物活性评估,用于发现β-N-乙酰基-D-己糖胺酶抑制剂。

蜕皮是必不可少的昆虫发育过程,其中涉及多种酶。这些酶的抑制作用会影响昆虫的正常生长和发育,甚至可能导致死亡。Hex1,所述β-之一Ñ乙酰基d己糖胺酶,是参与亚洲玉米螟的蜕皮过程中的关键酶(玉米螟),并且被认为是潜在的目标杀虫。
更新日期:2020-04-05
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