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Synthesis of novel 18β-glycyrrhetinic piperazine amides displaying significant in vitro and in vivo antibacterial activities against intractable plant bacterial diseases.
Pest Management Science ( IF 3.8 ) Pub Date : 2020-04-04 , DOI: 10.1002/ps.5841
Meng Xiang 1 , Ying-Lian Song 1 , Jin Ji 1 , Xiang Zhou 1 , Li-Wei Liu 1 , Pei-Yi Wang 1 , Zhi-Bing Wu 1 , Zhong Li 2 , Song Yang 1, 2
Affiliation  

The limited amount of agrochemicals targeting plant bacterial diseases has motivated us to study innovative antibacterial surrogates with fresh modes of action. Notably, fabrication of violent apoptosis inducers to control the reproduction of pathogenic bacteria should be a feasible way to control plant bacterial diseases. To achieve this aim, we constructed a series of novel 18β‐glycyrrhetinic piperazine amides based on the natural bioactive ingredient 18β‐glycyrrhetinic acid to evaluate the in vitro and in vivo antibacterial activity and induced apoptosis behaviors on tested pathogens.

中文翻译:

新型18β-甘草次酸哌嗪酰胺的合成显示出对难治性植物细菌疾病的显着体外和体内抗菌活性。

针对植物细菌疾病的农用化学品数量有限,促使我们研究具有新颖作用方式的创新型抗菌替代物。值得注意的是,制造强烈的凋亡诱导剂来控制病原菌的繁殖应该是控制植物细菌疾病的可行方法。要达到这个目的,我们构建了一系列新的18个的β基于所述天然生物活性成分18β-甘草哌嗪酰胺β β-甘草酸,以评估在体外体内的抗菌活性和对测试的病原体诱导的细胞凋亡的行为。
更新日期:2020-04-04
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