Integrated mRNA and microRNA transcriptome profiling during Differentiation of Human Nasal Polyp Epithelium reveals an altered Ciliogenesis,Allergy

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Integrated mRNA and microRNA transcriptome profiling during Differentiation of Human Nasal Polyp Epithelium reveals an altered Ciliogenesis
Allergy ( IF 12.6 ) Pub Date : 2020-07-06 , DOI: 10.1111/all.14307
Borja Callejas-Díaz _{1,

2} , Guerau Fernandez ₃ , Mireya Fuentes _{1,

2} , Asunción Martínez-Antón _{1,

4} , Isam Alobid _{1,

2,

5} , Jordi Roca-Ferrer _{1,

2} , César Picado _{1,

2,

6} , Valeria Tubita ₁ , Joaquim Mullol _{1,

2,

5}

Affiliation

Human adult basal stem/progenitor cells (BSCs) obtained from chronic rhinosinusitis with nasal polyps (CRSwNP) when differentiated in an air‐liquid interface (ALI) usually provide a pseudostratified airway epithelium with similar abnormalities than original in vivo phenotype. However, the intrinsic mechanisms regulating this complex process are not well defined and their understanding could offer potential new therapies for CRSwNP (incurable disease).

中文翻译：

人鼻息肉上皮分化过程中整合的 mRNA 和 microRNA 转录组分析揭示了纤毛发生的改变

从慢性鼻窦炎鼻息肉 (CRSwNP) 中获得的成人基底干/祖细胞 (BSC) 在气液界面 (ALI) 中分化时，通常会提供假复层气道上皮，其异常与原始体内表型相似。然而，调节这一复杂过程的内在机制尚未明确，他们的理解可以为 CRSwNP（不治之症）提供潜在的新疗法。

更新日期：2020-07-06

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