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Enzymes for pharmaceutical and therapeutic applications.
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-04-05 , DOI: 10.1002/bab.1919 Gautam Kumar Meghwanshi 1 , Navpreet Kaur 1 , Swati Verma 1 , Narendra Kumar Dabi 1 , Abhishek Vashishtha 1 , P D Charan 2 , Praveen Purohit 3 , H S Bhandari 4 , N Bhojak 4 , Rajender Kumar 5
Biotechnology and Applied Biochemistry ( IF 3.2 ) Pub Date : 2020-04-05 , DOI: 10.1002/bab.1919 Gautam Kumar Meghwanshi 1 , Navpreet Kaur 1 , Swati Verma 1 , Narendra Kumar Dabi 1 , Abhishek Vashishtha 1 , P D Charan 2 , Praveen Purohit 3 , H S Bhandari 4 , N Bhojak 4 , Rajender Kumar 5
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Enzymes are highly efficient and selective biocatalysts, present in the living beings. They exist in enormous varieties in terms of the types of reactions catalyzed by them for instance oxidation–reduction, group transfers within the molecules or between the molecules, hydrolysis, isomerization, ligation, bond cleavage, and bond formation. Besides, enzyme based catalyses are performed with much higher fidelity, under mild reaction conditions and are highly efficient in terms of number of steps, giving them an edge over their chemical counter parts. The unique characteristics of enzymes makes them highly applicable fora number of chemical transformation reactions in pharmaceutical industries, such as group protection and deprotection, selective acylation and deacylation, selective hydrolysis, deracemization, kinetic resolution of racemic mixtures, esterification, transesterification, and many others. In this review, an overview of the enzymes, their production and their applications in pharmaceutical syntheses and enzyme therapies are presented with diagrams, reaction schemes and table for easy understanding of the readers.
中文翻译：
用于药物和治疗应用的酶。
酶是存在于生物中的高效和选择性的生物催化剂。就它们催化的反应类型而言，它们种类繁多，例如氧化还原，分子内或分子间的基团转移，水解，异构化，连接，键断裂和键形成。此外，基于酶的催化剂在温和的反应条件下以更高的保真度进行，并且在步骤数方面非常高效，使其在化学对位部分上占优势。酶的独特特性使其非常适用于制药工业中的许多化学转化反应，例如基团保护和脱保护，选择性酰化和脱酰，选择性水解，脱硝，消旋混合物的动力学拆分，酯化，酯基转移等。在这篇综述中，通过图表，反应方案和表格对酶，酶的生产及其在药物合成和酶治疗中的应用进行了概述，以方便读者理解。
更新日期：2020-04-05
中文翻译：
用于药物和治疗应用的酶。
酶是存在于生物中的高效和选择性的生物催化剂。就它们催化的反应类型而言，它们种类繁多，例如氧化还原，分子内或分子间的基团转移，水解，异构化，连接，键断裂和键形成。此外，基于酶的催化剂在温和的反应条件下以更高的保真度进行，并且在步骤数方面非常高效，使其在化学对位部分上占优势。酶的独特特性使其非常适用于制药工业中的许多化学转化反应，例如基团保护和脱保护，选择性酰化和脱酰，选择性水解，脱硝，消旋混合物的动力学拆分，酯化，酯基转移等。在这篇综述中，通过图表，反应方案和表格对酶，酶的生产及其在药物合成和酶治疗中的应用进行了概述，以方便读者理解。
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