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Biomimicry of Cellular Motility and Communication Based on Synthetic Soft-Architectures.
Small ( IF 13.0 ) Pub Date : 2020-04-06 , DOI: 10.1002/smll.201907680
Lei Wang 1, 2 , Shidong Song 3 , Jan van Hest 3 , Loai K E A Abdelmohsen 3 , Xin Huang 1 , Samuel Sánchez 2, 4
Affiliation  

Cells, sophisticated membrane‐bound units that contain the fundamental molecules of life, provide a precious library for inspiration and motivation for both society and academia. Scientists from various disciplines have made great endeavors toward the understanding of the cellular evolution by engineering artificial counterparts (protocells) that mimic or initiate structural or functional cellular aspects. In this regard, several works have discussed possible building blocks, designs, functions, or dynamics that can be applied to achieve this goal. Although great progress has been made, fundamental—yet complex—behaviors such as cellular communication, responsiveness to environmental cues, and motility remain a challenge, yet to be resolved. Herein, recent efforts toward utilizing soft systems for cellular mimicry are summarized—following the main outline of cellular evolution, from basic compartmentalization, and biological reactions for energy production, to motility and communicative behaviors between artificial cell communities or between artificial and natural cell communities. Finally, the current challenges and future perspectives in the field are discussed, hoping to inspire more future research and to help the further advancement of this field.

中文翻译:

基于合成软架构的细胞运动和交流的仿生学。

细胞是包含生命基本分子的复杂的膜结合单元,为社会和学术界提供了宝贵的灵感和动力图书馆。来自各个学科的科学家已经通过模仿或启动结构或功能性细胞方面的工程化人工对应物(原始细胞),对理解细胞进化做出了巨大的努力。在这方面,几项工作讨论了可用于实现此目标的可能的构造块,设计,功能或动力学。尽管已经取得了长足的进步,但是诸如蜂窝通信,对环境线索的响应性以及移动性之类的基本行为(但仍然很复杂)仍然是一个挑战,有待解决。在这里 总结了最近在利用软系统进行细胞模拟中所做的努力-遵循了细胞进化的主要纲要,从基本的区室划分和产生能量的生物反应,到人工细胞群落之间或人工和天然细胞群落之间的运动性和交流行为。最后,讨论了该领域的当前挑战和未来前景,以期激发更多的未来研究并帮助该领域的进一步发展。
更新日期:2020-04-06
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