Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles.,Biomaterials Science

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Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles.
Biomaterials Science ( IF 5.8 ) Pub Date : 2020-05-06 , DOI: 10.1039/c9bm02019e
Peng-Hao Hsu ₁ , Carina Arboleda ₂ , Alexandra Stubelius ₃ , Ling-Wei Li ₃ , Jason Olejniczak ₁ , Adah Almutairi ₄

Affiliation

We synthesized an oxidation-responsive polycaprolactone (O-PCL) bearing pendant arylboronic esters as H2O2-responsive motifs. H2O2 induces fast depolymerization of O-PCL within days. Nanoparticles formulated from O-PCL disintegrate and release payload in response to concentrations of H2O2 (50 μM) that are relevant to human disease.

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