SynergyFinder (https://synergyfinder.fimm.fi) is a stand-alone web-application for interactive analysis and visualization of drug combination screening data. Since its first release in 2017, SynergyFinder has become a widely used web-tool both for the discovery of novel synergistic drug combinations in pre-clinical model systems (e.g. cell lines or primary patient-derived cells), and for better understanding of mechanisms of combination treatment efficacy or resistance. Here, we describe the latest version of SynergyFinder (release 2.0), which has extensively been upgraded through the addition of novel features supporting especially higher-order combination data analytics and exploratory visualization of multi-drug synergy patterns, along with automated outlier detection procedure, extended curve-fitting functionality and statistical analysis of replicate measurements. A number of additional improvements were also implemented based on the user requests, including new visualization and export options, updated user interface, as well as enhanced stability and performance of the web-tool. With these improvements, SynergyFinder 2.0 is expected to greatly extend its potential applications in various areas of multi-drug combinatorial screening and precision medicine.

中文翻译：

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SynergyFinder 2.0：多药组合协同作用的可视化分析。


SynergyFinder (https://synergyfinder.fimm.fi) 是一个独立的网络应用程序，用于药物组合筛选数据的交互式分析和可视化。自 2017 年首次发布以来，SynergyFinder 已成为广泛使用的网络工具，用于在临床前模型系统（例如细胞系或原代患者来源的细胞）中发现新型协同药物组合，以及更好地了解协同药物组合的机制联合治疗的疗效或耐药性。在这里，我们描述了最新版本的 SynergyFinder（2.0 版），该版本通过添加新功能进行了广泛升级，特别支持高阶组合数据分析和多药物协同模式的探索性可视化，以及自动异常值检测程序，扩展的曲线拟合功能和重复测量的统计分析。根据用户请求还实施了许多其他改进，包括新的可视化和导出选项、更新的用户界面以及增强的网络工具稳定性和性能。通过这些改进，SynergyFinder 2.0有望极大扩展其在多药组合筛选和精准医疗各个领域的潜在应用。