Hippocampal neurons represent events as transferable units of experience.,Nature Neuroscience

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Hippocampal neurons represent events as transferable units of experience.
Nature Neuroscience ( IF 21.2 ) Pub Date : 2020-04-06 , DOI: 10.1038/s41593-020-0614-x
Chen Sun ₁ , Wannan Yang ₂ , Jared Martin ₁ , Susumu Tonegawa _{1,

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Affiliation

The brain codes continuous spatial, temporal and sensory changes in daily experience. Recent studies suggest that the brain also tracks experience as segmented subdivisions (events), but the neural basis for encoding events remains unclear. Here, we designed a maze for mice, composed of four materially indistinguishable lap events, and identify hippocampal CA1 neurons whose activity are modulated not only by spatial location but also lap number. These 'event-specific rate remapping' (ESR) cells remain lap-specific even when the maze length is unpredictably altered within trials, which suggests that ESR cells treat lap events as fundamental units. The activity pattern of ESR cells is reused to represent lap events when the maze geometry is altered from square to circle, which suggests that it helps transfer knowledge between experiences. ESR activity is separately manipulable from spatial activity, and may therefore constitute an independent hippocampal code: an 'event code' dedicated to organizing experience by events as discrete and transferable units.

中文翻译：

海马神经元将事件表示为可转移的经验单位。

大脑对日常经验中连续的空间、时间和感官变化进行编码。最近的研究表明，大脑也将经验作为分段细分（事件）进行跟踪，但编码事件的神经基础仍不清楚。在这里，我们为小鼠设计了一个迷宫，由四个实质上无法区分的圈事件组成，并识别出海马 CA1 神经元，其活动不仅受到空间位置的调节，而且还受到圈数的调节。即使迷宫长度在试验中不可预测地改变，这些“事件特异性速率重映射”（ESR）细胞仍然具有单圈特异性，这表明 ESR 细胞将单圈事件视为基本单位。当迷宫几何形状从方形变为圆形时，ESR 细胞的活动模式被重新用于表示单圈事件，这表明它有助于在经验之间传递知识。 ESR活动可以与空间活动分开操纵，因此可能构成一个独立的海马代码：一个致力于将事件的经验组织为离散和可转移单位的“事件代码”。

更新日期：2020-04-06

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