Cancer-related deaths did not apparently decrease in the past decades despite aggressive treatments. It's reported that cancer will become the leading cause of death worldwide in the twenty-first century. Increasing evidence has revealed that lncRNAs will emerge as promising cancer biomarkers or therapeutic targets in cancer treatment. LncRNA-ATB, a long noncoding RNA activated by TGF-β, was found to be abnormally expressed in certain cancers and participate in the development and progression of tumors. In addition, aberrant lncRNA-ATB expression was also associated with clinical characteristics of tumors. The purpose of this review is to summarize functions and underlying mechanisms of lncRNA-ATB in tumors, and discuss whether lncRNA-ATB can be a biomarker and therapeutic target in cancers.

中文翻译：

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LncRNA-ATB在癌症中的作用：到目前为止我们知道什么？

尽管采取了积极的治疗措施，在过去的几十年中，与癌症相关的死亡并未明显减少。据报道，癌症将成为二十一世纪全球死亡的主要原因。越来越多的证据表明，lncRNAs将成为有前途的癌症生物标志物或癌症治疗中的治疗靶标。发现LncRNA-ATB是一种由TGF-β激活的长的非编码RNA，在某些癌症中异常表达，并参与肿瘤的发生和发展。此外，lncRNA-ATB异常表达也与肿瘤的临床特征有关。这篇综述的目的是总结lncRNA-ATB在肿瘤中的功能和潜在机制，并讨论lncRNA-ATB是否可以作为癌症的生物标志物和治疗靶标。