Brain damage related to perinatal asphyxia is the second cause of neuro-disability worldwide. Its incidence was estimated in 2010 as 8.5 cases per 1000 live births worldwide, with no further recent improvement even in more industrialized countries. If so, hypoxic-ischemic encephalopathy is still an issue of global health concern. It is thought that a consistent number of cases may be avoided, and its sequelae may be preventable by a prompt and efficient physical and therapeutic treatment. The lack of early, reliable, and specific biomarkers has up to now hampered a more effective use of hypothermia, which represents the only validated therapy for this condition. The urge to unravel the biological modifications underlying perinatal asphyxia and hypoxic-ischemic encephalopathy needs new diagnostic and therapeutic tools. Metabolomics for its own features is a powerful approach that may help for the identification of specific metabolic profiles related to the pathological mechanism and foreseeable outcome. The metabolomic profiles of animal and human infants exposed to perinatal asphyxia or developing hypoxic-ischemic encephalopathy have so far been investigated by means of ¹H nuclear magnetic resonance spectroscopy and mass spectrometry coupled with gas or liquid chromatography, leading to the identification of promising metabolomic signatures. In this work, an extensive review of the relevant literature was performed.

中文翻译：

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通过代谢组学探索围产期窒息。

与围产期窒息有关的脑损伤是全世界神经残疾的第二个原因。据估计，2010年其发病率在全球每千名活产婴儿中有8.5例，即使在工业化程度更高的国家，近期也没有进一步改善。如果是这样，那么缺氧缺血性脑病仍然是全球健康问题。据认为，可以避免大量病例，并且通过快速有效的物理和治疗方法可以预防其后遗症。迄今为止，缺乏早期，可靠和特异性的生物标志物阻碍了低温疗法的更有效利用，低温疗法是针对这种情况的唯一经过验证的疗法。揭开围产期窒息和缺氧缺血性脑病的生物学改变的冲动需要新的诊断和治疗工具。代谢组学自身的功能是一种有力的方法，可帮助鉴定与病理机制和可预见结果有关的特定代谢谱。迄今为止，已经通过以下方法研究了暴露于围生期窒息或发生缺氧缺血性脑病的动物和人类婴儿的代谢组学特征。¹ H核磁共振波谱和质谱结合气相色谱或液相色谱，可鉴定出有希望的代谢组学特征。在这项工作中，对相关文献进行了广泛的回顾。