Tissue-resident memory T (T_RM) cells exist throughout the body, where they are poised to mediate local immune responses. Although studies have defined a common mechanism of residency independent of location, there is likely to be a level of specialization that adapts T_RM cells to their given tissue of lodgment. It has been shown that T_RM cells in the skin rely on the uptake of exogenous fatty acids for their survival and up-regulate fatty acid–binding protein 4 (FABP4) and FABP5 as part of their transcriptional program. However, FABPs exist as a larger family of isoforms, with different members selected in a tissue-specific fashion that is optimized for local fatty acid availability. Here, we show that although T_RM cells in a range of tissue widely express FABPs, they are not restricted to FABP4 and FABP5. Instead, T_RM cells show varying patterns of isoform usage that are determined by tissue-derived factors. These patterns are malleable because T_RM cells relocated to different organs modify their FABP expression in line with their new location. As a consequence, these results argue for tissue-specific overlays to the T_RM cell residency program, including FABP expression that is tailored to the particular tissue of T_RM cell lodgment.

组织驻留记忆T（T _RM）细胞遍布全身，准备介导局部免疫反应。尽管研究已经定义了一种与位置无关的通用驻留机制，但是可能存在一定程度的专业化水平，可以使T _RM细胞适应其给定的住宿组织。研究表明，皮肤中的T _RM细胞依赖于摄取外源脂肪酸来维持生存，并作为转录程序的一部分上调脂肪酸结合蛋白4（FABP4）和FABP5。但是，FABP以较大的同工型形式存在，并且以针对特定脂肪酸的最佳化的组织特异性方式选择了不同的成员。在这里，我们表明尽管T _RM一系列组织中的细胞广泛表达FABP，但不限于FABP4和FABP5。取而代之的是，T _RM细胞显示出不同的同种型使用模式，这些模式由组织衍生的因子决定。这些模式具有延展性，因为重新定位到不同器官的T _RM细胞会根据其新位置修改其FABP表达。因此，这些结果主张组织特异性叠加到T _RM细胞居住方案，包括被定制为T的特定组织FABP表达_RM细胞立足点。