Sepsis-associated encephalopathy (SAE) often leads to cognitive impairments in the rest life of septic survivors. The potential pathological changes of SAE are complicated and have not been fully understood. Morin, a flavone compound exhibiting neuroprotective activity and anti-inflammation effect, was employed to treat with CLP-induced septic mice in our study. The data from a novel object recognition test and tail suspension test indicated that morin treatment reversed cognitive dysfunction and relieved depressive-like behaviors in septic mice. Morin down-regulated the expressions of IL-6, MCP-1, TNF-α and IL-10 in serum and diminished microglia activation in septic mice. Additionally, Western blot results showed that morin reduced the phosphokinase GSK3β activity and elevated the phosphatase PP2A activity, which led to lower tau phosphorylation. Morin reduced Aβ deposition and protected the synapse integrity, which might be the possible mechanism of protecting cognitive functions in septic mice. In conclusion, we identified that morin exerted anti-inflammation and anti-neurodegeneration effects in septic mice, and prevented further cognitive impairments.

中文翻译：

---

Morin 对鼠脓毒症模型中的脑病和脓毒症相关认知功能发挥保护作用。

脓毒症相关脑病 (SAE) 通常会导致脓毒症幸存者在余生中出现认知障碍。SAE的潜在病理变化很复杂，尚未完全了解。Morin 是一种具有神经保护活性和抗炎作用的黄酮化合物，在我们的研究中被用于治疗 CLP 诱导的败血症小鼠。来自新物体识别测试和悬尾测试的数据表明，morin 治疗逆转了败血症小鼠的认知功能障碍并缓解了抑郁样行为。Morin 下调血清中 IL-6、MCP-1、TNF-α 和 IL-10 的表达，减少脓毒症小鼠的小胶质细胞活化。此外，蛋白质印迹结果显示，morin 降低磷酸激酶 GSK3β 活性并提高磷酸酶 PP2A 活性，从而降低 tau 磷酸化。Morin 减少 Aβ 沉积并保护突触完整性，这可能是保护脓毒症小鼠认知功能的机制。总之，我们确定桑椹素在败血症小鼠中发挥抗炎和抗神经变性作用，并防止进一步的认知障碍。