Mechanisms of Ageing and Development ( IF 5.3 ) Pub Date : 2020-04-03 , DOI: 10.1016/j.mad.2020.111230 Daria Khaltourina 1 , Yuri Matveyev 2 , Aleksey Alekseev 3 , Franco Cortese 4 , Anca Ioviţă 5
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The disease criteria used by the World Health Organization (WHO) were applied to human biological aging in order to assess whether aging can be classified as a disease. These criteria were developed for the 11th revision of the International Classification of Diseases (ICD) and included disease diagnostics, mechanisms, course and outcomes, known interventions, and linkage to genetic and environmental factors.
Results
Biological aging can be diagnosed with frailty indices, functional, blood-based biomarkers. A number of major causal mechanisms of human aging involved in various organs have been described, such as inflammation, replicative cellular senescence, immune senescence, proteostasis failures, mitochondrial dysfunctions, fibrotic propensity, hormonal aging, body composition changes, etc. We identified a number of clinically proven interventions, as well as genetic and environmental factors of aging. Therefore, aging fits the ICD-11 criteria and can be considered a disease. Our proposal was submitted to the ICD-11 Joint Task force, and this led to the inclusion of the extension code for “Ageing-related” (XT9T) into the “Causality” section of the ICD-11. This might lead to greater focus on biological aging in global health policy and might provide for more opportunities for the new therapy developers.
中文翻译：
老龄化符合国际疾病分类的疾病标准。
世界卫生组织（WHO）使用的疾病标准被应用于人类生物衰老，以评估衰老是否可以归类为疾病。这些标准是针对《国际疾病分类》（ICD）的第11版制定的，包括疾病诊断，机制，病程和结果，已知干预措施以及与遗传和环境因素的联系。
结果
衰老指数，功能性，基于血液的生物标记物可以诊断生物衰老。已经描述了涉及各个器官的许多人类衰老的主要成因机制，例如炎症，复制性细胞衰老，免疫衰老，蛋白变性失败，线粒体功能障碍，纤维化倾向，激素衰老，身体组成变化等。我们确定了许多临床证明的干预措施，以及衰老的遗传和环境因素。因此，衰老符合ICD-11标准，可以视为疾病。我们的提案已提交给ICD-11联合工作组，这导致将“与年龄相关”（XT9T）的扩展代码包含在ICD-11的“因果关系”部分中。
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