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Biomonitoring of bisphenols A, F, S and parabens in urine of breastfeeding mothers: Exposure and risk assessment.
Environmental Research ( IF 7.7 ) Pub Date : 2020-04-05 , DOI: 10.1016/j.envres.2020.109481
Yovana Sanchis 1 , Clara Coscollà 1 , Francisca Corpas-Burgos 2 , Máximo Vento 3 , María Gormaz 3 , Vicent Yusà 4 ,
Affiliation  

In the present study we used human biomonitoring to assess the internal exposure and the risk to four parabens and three bisphenols in 103 Spanish breastfeeding mothers participating in the BETTERMIILK project. Urinary methylparaben (MP), ethylparaben (EP), propylparaben (PP) and butylparaben (BP) presented detection frequencies ranging from 12% (BP) to 92% (MP), while bisphenol A (BPA), bisphenol F (BPF) and bisphenol S (BPS) were detected in 76% (BPA) and 20% (BPF, BPS) of the mothers. Average paraben concentrations (geometric mean) ranged from 0.021 ng mL-1 (BP) to 17.7 ng mL-1 (MP), whereas bisphenols had geometric means concentrations from 0.042 ng mL-1 (BPF) to 0.927 ng mL-1 (BPA). Except for BPA, the estimated daily intakes (EDI) were calculated in order to interpret urinary levels in a risk assessment context. The obtained EDIs ranged from 0.00042 mg/kg/day for PP to 0.0434 mg/kg/day for MP and EP. A hazard quotient (HQ) was calculated for BPA (0.0049) and parabens (0.001-0.004), showing no risk in the studied population. Sociodemographic characteristics, food consumption, and usage patterns of personal care products (PCPs) were investigated as possible determinants of exposure. Use of makeup and skincare products were associated with higher concentrations of MP and PP, respectively. Regarding dietary habits, MP was also associated with the consumption of packaged and bakery products.

中文翻译:

母乳喂养母亲尿液中双酚A,F,S和对羟基苯甲酸酯的生物监测:暴露和风险评估。

在本研究中,我们使用人类生物监测评估了参与BETTERMIILK项目的103名西班牙母乳喂养母亲的内部暴露以及四种对羟基苯甲酸酯和三种双酚的风险。尿对羟基苯甲酸甲酯(MP),对羟基苯甲酸乙酯(EP),对羟基苯甲酸丙酯(PP)和对羟基苯甲酸丁酯(BP)的检测频率范围为12%(BP)至92%(MP),而双酚A(BPA),双酚F(BPF)和在76%(BPA)和20%(BPF,BPS)的母亲中检出了双酚S(BPS)。对羟基苯甲酸酯的平均浓度(几何平均值)为0.021 ng mL-1(BP)至17.7 ng mL-1(MP),而双酚的几何平均浓度为0.042 ng mL-1(BPF)至0.927 ng mL-1(BPA) )。除双酚A外,还计算了估计的每日摄入量(EDI),以便在风险评估中解释尿液的水平。所获得的EDI从PP的0.00042 mg / kg /天到MP和EP的0.0434 mg / kg /天。计算出BPA(0.0049)和对羟基苯甲酸酯(0.001-0.004)的危险商(HQ),表明在所研究的人群中没有危险。调查了社会人口统计学特征,食物消耗和个人护理产品(PCPs)的使用方式,这些因素可能是暴露的决定因素。化妆和护肤产品的使用分别与较高的MP和PP浓度有关。关于饮食习惯,MP也与包装和烘焙产品的消费有关。调查了个人护理产品(PCP)的使用和使用方式,将其作为暴露的可能决定因素。化妆和护肤产品的使用分别与较高的MP和PP浓度有关。关于饮食习惯,MP也与包装和烘焙产品的消费有关。调查了个人护理产品(PCP)的使用和使用方式,将其作为暴露的可能决定因素。化妆和护肤产品的使用分别与较高的MP和PP浓度有关。关于饮食习惯,MP也与包装和烘焙产品的消费有关。
更新日期:2020-04-06
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