Abstract Bone tissue engineering has become one of the most effective methods for treating bone defects. In this study, an electrospun tissue engineering membrane containing magnesium was successfully fabricated by incorporating magnesium oxide (MgO) nanoparticles into silk fibroin and polycaprolactone (SF/PCL)-blend scaffolds. The release kinetics of Mg2+ and the effects of magnesium on scaffold morphology, and cellular behavior were investigated. The obtained Mg-functionalized nanofibrous scaffolds displayed controlled release of Mg2+, satisfactory biocompatibility and osteogenic capability. The in vivo implantation of magnesium-containing electrospun nanofibrous membrane in a rat calvarial defect resulted in the significant enhancement of bone regeneration twelve weeks post-surgery. This work represents a valuable strategy for fabricating functional magnesium-containing electrospun scaffolds that show potential in craniofacial and orthopedic applications.

中文翻译：

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用于加速骨再生的含镁丝蛋白/聚己内酯电纺纳米纤维支架

摘要 骨组织工程已成为治疗骨缺损最有效的方法之一。在这项研究中，通过将氧化镁 (MgO) 纳米颗粒掺入丝素蛋白和聚己内酯 (SF/PCL) 混合支架中，成功制造了一种含镁的电纺组织工程膜。研究了 Mg2+ 的释放动力学和镁对支架形态和细胞行为的影响。获得的镁功能化纳米纤维支架显示出可控的 Mg2+ 释放、令人满意的生物相容性和成骨能力。含镁电纺纳米纤维膜在大鼠颅骨缺损中的体内植入导致术后 12 周骨再生的显着增强。