Abstract Recently tissue repairing bone grafted materials have been greater properties than the recapitulating intramembranous regeneration of natural bone especially cartilage damage regeneration. In this present work was designed and developed for the enhancement of chondrocyte generation for cartilage repair. Boswellic acid (BA) is a traditional compound used for the treatment of osteoarthritis. Boswellic acid subjected to involve the preparation of hydroxyapatite (HAP) and HAP-BA compounds were functionalized with carboxymethyl cellulose (CMC) to promote the extra-cellular matrix. HAP, HAP-BA and HAP-BA-CMC composites were characterized via their physicochemical properties through FTIR, XRD, SEM and TEM techniques. The antibacterial activity and chondrocyte cell variability were tested. At 14 days, HAP-BA-CMC composite was observed 67% of cell viability. The chondrocyte cell adhesion on the HAP-BA-CMC composite was investigated and it observed polygonal filopodia. From the results suggest that HAP-BA-CMC composite can improve the chondrocyte production for repair of damaged cartilage.

中文翻译：

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乳香酸捕获的羟基磷灰石羧甲基纤维素复合物用于增强软骨细胞修复软骨

摘要 近来组织修复骨移植材料具有比自然骨的再生膜内再生尤其是软骨损伤再生更大的特性。在目前的工作中，设计和开发用于增强软骨细胞生成以进行软骨修复。乳香酸 (BA) 是一种用于治疗骨关节炎的传统化合物。参与制备羟基磷灰石 (HAP) 和 HAP-BA 化合物的乳香酸用羧甲基纤维素 (CMC) 功能化以促进细胞外基质。HAP、HAP-BA 和 HAP-BA-CMC 复合材料通过 FTIR、XRD、SEM 和 TEM 技术通过其理化性质进行表征。测试了抗菌活性和软骨细胞变异性。在第 14 天，观察到 HAP-BA-CMC 复合物有 67% 的细胞活力。研究了 HAP-BA-CMC 复合材料上的软骨细胞粘附，并观察到多边形丝状伪足。结果表明HAP-BA-CMC复合物可以提高软骨细胞的产生以修复受损的软骨。