Abstract High transparent and biocompatible hydrogel dressing with bioactivity is attractive for clinical skin repair. Here we report a high optically transparent interpenetrating network (IPN) hydrogel that was fabricated by sericin and polyacrylamide. The hydrogels possess pH-dependent degradation as well as high porosity and porous structures with different sized diameters and distribution. Moreover, the swelling behaviors, degradation dynamics, and mechanical strength can be flexibly regulated by adjusting the content of sericin. In addition, the hydrogel system is compatible with hosting cells owing to its excellent cell-adhesive capability, effectively promoting cell attachment, proliferation and long-term survival. Together, our study demonstrates that the sericin-polyacrylamide interpenetrating network hydrogel may serve as a visualized dressing material for real-time monitoring of wounds.

中文翻译：

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透明丝胶-聚丙烯酰胺互穿网络水凝胶可视化敷料

摘要 具有生物活性的高透明、生物相容性水凝胶敷料对临床皮肤修复具有重要意义。在这里，我们报告了一种由丝胶和聚丙烯酰胺制造的高光学透明互穿网络 (IPN) 水凝胶。水凝胶具有 pH 依赖性降解以及具有不同尺寸直径和分布的高孔隙率和多孔结构。此外，可以通过调节丝胶含量来灵活调节溶胀行为、降解动力学和机械强度。此外，水凝胶系统具有优异的细胞粘附能力，可与宿主细胞相容，有效促进细胞附着、增殖和长期存活。一起，