The statin family of drugs are safe and effective therapeutic agents for the treatment of arteriosclerotic cardiovascular disease (CVD). Due to a wide range of health benefits in addition to their cholesterol lowering properties, statins have recently attracted significant attention as a new treatment strategy for several conditions, which are not directly related to normalizing a lipid profile and preventing CVD. Statins exert a variety of beneficial effects on different aspects of oral health, which includes their positive effects on bone metabolism, their anti-inflammatory and antioxidant properties, and their potential effects on epithelization and wound healing. Additionally, they possess antimicrobial, antiviral, and fungicidal properties, which makes this class of drugs attractive to the field of periodontal diseases and oral and dental health. However, to the best of our knowledge, there has been no comprehensive study to date, which has investigated the effects of statin drugs on different aspects of dental and oral health. Therefore, the primary objective of this paper was to review the effect of statins on dental and oral health. Results of our extensive review have indicated that statins possess remarkable and promising effects on several aspects of dental and oral health including chronic periodontitis, alveolar bone loss due to either extraction or chronic periodontitis, osseointegration of implants, dental pulp cells, orthodontic tooth movement, and orthodontic relapse, tissue healing (wound/bone healing), salivary gland function, and finally, anti-cancer effects. Hence, statins can be considered as novel, safe, inexpensive, and widely-accessible therapeutic agents to improve different aspects of dental and oral health.

中文翻译：

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他汀类药物对牙齿和口腔健康的影响：临床前和临床研究综述。

他汀类药物家族是治疗动脉硬化性心血管疾病（CVD）的安全有效的治疗药物。由于除了降低胆固醇的特性外，他汀类药物还具有广泛的健康益处，因此他汀类药物最近作为治疗多种疾病的新治疗策略引起了广泛关注，这些疾病与血脂正常化和预防心血管疾病没有直接关系。他汀类药物对口腔健康的不同方面发挥着多种有益作用，包括对骨代谢的积极作用、抗炎和抗氧化特性，以及对上皮形成和伤口愈合的潜在影响。此外，它们还具有抗菌、抗病毒和杀菌特性，这使得此类药物对牙周疾病和口腔和牙齿健康领域具有吸引力。然而，据我们所知，迄今为止还没有全面的研究调查他汀类药物对牙齿和口腔健康不同方面的影响。因此，本文的主要目的是回顾他汀类药物对牙齿和口腔健康的影响。我们广泛审查的结果表明，他汀类药物对牙齿和口腔健康的多个方面具有显着且有前景的作用，包括慢性牙周炎、拔牙或慢性牙周炎引起的牙槽骨丢失、种植体的骨整合、牙髓细胞、正畸牙齿移动和正畸复发、组织愈合（伤口/骨骼愈合）、唾液腺功能，最后是抗癌作用。因此，他汀类药物可被认为是新型、安全、廉价且可广泛使用的治疗药物，可改善牙齿和口腔健康的各个方面。