This study aimed to explore the molecular mechanism of osteoarthritis (OA) and provide information about new genes as potential targets for OA treatment. Gene expression profile of GSE105027, including 12 OA serum samples (OA group) and 12 healthy serum samples (ctrl group), was downloaded. The differentially expressed miRNAs (DEMs) as well as miRNA-mRNAs interactions were investigated, followed by function and pathway investigation. Then the protein-protein interaction (PPI) network was performed. Furthermore, the long non-coding RNA (lncRNA)-miRNA-mRNA interactions (competing endogenous RNAs, ceRNAs) were investigated. A total of 17 downregulated miRNAs were revealed between OA and ctrl groups. These DEMs such as has-miR-1202 were mainly enriched in GO functions like histone acetyltransferase binding and KEGG pathways like cellular senescence. The integrated PPI network analysis showed that has-miR-1202, has-miR-33b-3p, has-miR-940, has-miR-4284, and has-miR-4281 were 5 downregulated miRNAs in this network. Furthermore, the lncRNA-miRNA-mRNA interactions such as KCNQ1OT1-has-miR-1202-ETS1 were revealed in the present ceRNA network. Key DEMs such as miR-33b-3p, miR-940, and miR-1202 may be involved in OA. miR-1202 may regulate OA development via histone acetyltransferase pathway binding function and cellular senescence pathway. Furthermore, KCNQ1OT1-has-miR-1202-ETS1 might be vital for the process of OA.

中文翻译：

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MicroRNA-1202通过KCNQ1OT1 has-miR-1202-ETS1调节途径在骨关节炎中起着至关重要的作用

这项研究旨在探讨骨关节炎（OA）的分子机制，并提供有关新基因作为OA治疗潜在靶点的信息。下载了GSE105027的基因表达谱，包括12个OA血清样品（OA组）和12个健康血清样品（ctrl组）。研究了差异表达的miRNA（DEM）以及miRNA-mRNA的相互作用，然后进行了功能和途径研究。然后进行蛋白质间相互作用（PPI）网络。此外，研究了长时间的非编码RNA（lncRNA）-miRNA-mRNA相互作用（竞争内源性RNA，ceRNA）。在OA组和ctrl组之间总共发现了17个下调的miRNA。这些DEM（例如has-miR-1202）主要富含GO功能（如组蛋白乙酰转移酶结合）和KEGG途径（如细胞衰老）。集成的PPI网络分析显示has-miR-1202，has-miR-33b-3p，has-miR-940，has-miR-4284和has-miR-4281是该网络中的5个下调的miRNA。此外，在当前的ceRNA网络中揭示了lncRNA-miRNA-mRNA相互作用，例如KCNQ1OT1-has-miR-1202-ETS1。关键的DEM（例如miR-33b-3p，miR-940和miR-1202）可能与OA有关。miR-1202可能通过组蛋白乙酰转移酶途径的结合功能和细胞衰老途径来调节OA的发育。此外，KCNQ1OT1-has-miR-1202-ETS1可能对OA过程至关重要。在目前的ceRNA网络中揭示了lncRNA-miRNA-mRNA相互作用，例如KCNQ1OT1-has-miR-1202-ETS1。关键的DEM（例如miR-33b-3p，miR-940和miR-1202）可能与OA有关。miR-1202可能通过组蛋白乙酰转移酶途径的结合功能和细胞衰老途径来调节OA的发育。此外，KCNQ1OT1-has-miR-1202-ETS1可能对OA过程至关重要。在目前的ceRNA网络中揭示了lncRNA-miRNA-mRNA相互作用，例如KCNQ1OT1-has-miR-1202-ETS1。关键的DEM，例如miR-33b-3p，miR-940和miR-1202可能与OA有关。miR-1202可能通过组蛋白乙酰转移酶途径的结合功能和细胞衰老途径来调节OA的发育。此外，KCNQ1OT1-has-miR-1202-ETS1可能对OA过程至关重要。