BACKGROUND Real-World Data (RWD) studies provide important insights in disease epidemiology, in real clinical populations, with long follow-up periods. The aim of the present study was to describe the epidemiology of schizophrenia spectrum disorders (SD) during an 8-year period in Spain. METHODS A retrospective cohort of subjects aged 15 to 64 years was followed-up using electronic healthcare databases of the Valencia region (2008-2015). SD cases included outpatient and inpatient settings (ICD 9 codes 295.XX). Prevalence of SD was assessed. Incidence rate (IR) in the subpopulation aged between 15 and 34 years was also provided. Healthcare utilization (HCU) rates, including outpatient, specialists, hospitalizations and antipsychotic dispensations were estimated. RESULTS The cohort included 3,976,071 subjects; 24,749 of them had a prevalent diagnosis of SD. The overall prevalence for SD was 6.2 per 1000 persons. SD were 76% more prevalent in men than women. IR in the subpopulation aged between 15 and 34 years was 50.25 per 100,000 persons years and was more than 2 times higher for men than for women. 83.4% of the overall outpatient visits from the cohort of patients were related to SD. The 21,095 overall hospitalizations with the SD code resulted in 286,139 days of hospitalization, with a median of 4 days (IQR: 1.6-9.2) per person-year. 93.2% of subjects diagnosed with SD were ever treated with some antipsychotic drug during the study period, and 70% of the patients were ever treated with antipsychotic polypharmacy. CONCLUSIONS This large population-based study using RWD provides novel and recent information SD in a southern European country. The prevalence and IR of SD showed is greater than previously published and higher in men than in women. The fact of having used a large arsenal of electronic data (including outpatient and inpatient) for 8 years may have influenced. SD represents high burden and healthcare utilization. Contrary to guidelines recommendations the majority of patients were ever treated with antipsychotic polypharmacy.

中文翻译：

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使用西班牙的实际数据，对精神分裂症的流行病学及其在8年期间的管理。

背景技术真实世界数据（RWD）研究提供了对具有长期随访期的实际临床人群中疾病流行病学的重要见解。本研究的目的是描述西班牙在8年期间的精神分裂症谱系疾病（SD）的流行病学。方法使用瓦伦西亚地区（2008-2015年）的电子医疗数据库对年龄在15至64岁之间的受试者进行回顾性队列研究。SD病例包括门诊和住院设置（ICD 9代码295.XX）。评估SD的患病率。还提供了年龄在15至34岁之间的亚人群的发病率（IR）。估计了医疗保健利用率（HCU），包括门诊，专科医生，住院和抗精神病药的发放。结果该队列包括3,976,071名受试者；24 他们中有749位普遍诊断为SD。SD的总患病率为每1000人6.2。男性的SD比女性高76％。在15至34岁之间的亚人群中，IR率为每10万人年50.25，并且男性比女性高2倍以上。来自患者队列的全部门诊就诊人数中有83.4％与SD相关。使用SD代码的21,095例总体住院治疗导致286,139天的住院治疗，平均每人年为4天（IQR：1.6-9.2）。在研究期间，有93.2％的被诊断为SD的受试者曾接受过某种抗精神病药物的治疗，而70％的患者曾接受过抗精神病的多药治疗。结论这项使用RWD的大型人群研究提供了一个南部欧洲国家的新颖和最新的信息SD。SD的患病率和IR高于以前发表的数据，男性高于女性。使用大型电子数据库（包括门诊和住院病人）已有8年的事实可能会产生影响。SD代表高负担和医疗保健利用率。与指南的建议相反，大多数患者曾接受过抗精神病药的治疗。