BACKGROUND Herein, we collected currently published data to comprehensively evaluate the impact of the FCGR2A (Fc fragment of IgG receptor IIa) rs1801274 and MUC5B (mucin 5B, oligomeric mucus/gel-forming) rs35705950 variations on susceptibility to pneumonia diseases. METHODS We retrieved case-control studies from three online databases and applied the statistical approach of meta-analysis for a series of pooling analyses. RESULTS A total of fourteen case-control studies were included for FCGR2A rs1801274; while thirty-one case-control studies were included for MUC5B rs35705950. No significant difference between pneumonia cases and controls for FCGR2A rs1801274 was found. However, MUC5B rs35705950 was significantly associated with pneumonia susceptibility in the whole population under the genetic models of allelic T vs. G [OR (odds ratio) =3.78], carrier T vs. G (OR = 3.31), TT vs. GG (OR = 13.66), GT vs. GG (OR = 4.78), GT + TT vs. GG (OR = 5.05), and TT vs. GG + GT (OR = 6.47) (all P < 0.001, Bonferroni-adjusted P < 0.006; false discovery rate-adjusted P < 0.0010). Furthermore, we observed a similar positive result for subgroup analyses of "Caucasian", "Asian", "population-based control", and "idiopathic pulmonary fibrosis". CONCLUSIONS MUC5B rs35705950, but not FCGR2A rs1801274, increases susceptibility to clinical pneumonia, especially to idiopathic pulmonary fibrosis, in both the Caucasian and Asian populations.

中文翻译：

---

FCGR2A rs1801274和MUC5B rs35705950变异与肺炎易感性之间的关联。

背景技术在此，我们收集了当前发表的数据，以全面评估FCGR2A（IgG受体IIa的Fc片段）rs1801274和MUC5B（粘蛋白5B，低聚粘液/凝胶形成）rs35705950变异对肺炎疾病易感性的影响。方法我们从三个在线数据库中检索了病例对照研究，并将荟萃分析的统计方法应用于一系列合并分析。结果总共纳入了十四项针对FCGR2A rs1801274的病例对照研究；而对MUC5B rs35705950进行了31例病例对照研究。未发现肺炎病例与FCGR2A rs1801274的对照之间有显着差异。然而，在等位基因T与G的遗传模型下，MUC5B rs35705950与整个人群的肺炎易感性显着相关[OR（比值比）= 3.78]，载波T对G（OR = 3.31），TT对GG（OR = 13.66），GT对GG（OR = 4.78），GT + TT对GG（OR = 5.05）和TT对GG + GT （OR = 6.47）（所有P <0.001，经Bonferroni调整的P <0.006；错误发现率调整的P <0.0010）。此外，对于“高加索人”，“亚洲人”，“基于人群的对照”和“特发性肺纤维化”的亚组分析，我们观察到了相似的阳性结果。结论MUC5B rs35705950（而不是FCGR2A rs1801274）增加了白种人和亚洲人群对临床肺炎的敏感性，特别是对特发性肺纤维化的敏感性。0010）。此外，对于“高加索人”，“亚洲人”，“基于人群的对照”和“特发性肺纤维化”的亚组分析，我们观察到了相似的阳性结果。结论MUC5B rs35705950（而不是FCGR2A rs1801274）增加了白种人和亚洲人群对临床肺炎的敏感性，特别是对特发性肺纤维化的敏感性。0010）。此外，对于“高加索人”，“亚洲人”，“基于人群的对照”和“特发性肺纤维化”的亚组分析，我们观察到了相似的阳性结果。结论MUC5B rs35705950（而不是FCGR2A rs1801274）增加了白种人和亚洲人群对临床肺炎的敏感性，特别是对特发性肺纤维化的敏感性。