BACKGROUND There is still controversy over the clinical interpretation of the association between metabolic syndrome (MetS) and serum uric acid (SUA) levels. Therefore, the aim of this study was to investigate the association of SUA levels with MetS and other cardio-metabolic risk factors (CMRF) in seafarers working on tankers. METHODS This cross-sectional study was conducted in 2015 and included 234 male seafarers working on tankers. The participants were divided into three groups based on the tertiles of SUA. The report from of the National Committee of Obesity was used to define the MetS. The relationship between SUA, CMRF and MetS adjusted for age, educational level, job history, shift work, smoking and BMI was assessed by logistic regression analysis. RESULTS The subjects were aged 36.0 ± 10.3 years (mean ± SD). A notable upward trend was observed in mean weight, body mass index (BMI), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and very low-density lipoprotein (VLDL) as tertiles of SUA increased (P < 0.001). In all models of the logistic regression analyses, the odds ratio (OR) of high TG for participants in the 3rd tertile of SUA was four times higher than that for participants in the 1st tertile of SUA (P < 0.001). The odds ratio of high TC and the SUA levels increased, so that the odds ratio of high TC for participants in the 2nd tertile was 2.47 (95% CI: 1.10-5.53) (P < 0.05) as compared with that for participants in the 1st tertile. Significant association was observed between MetS and the levels of SUA; 6.10 (95% CI: 1.77-20.94) (P < 0.05). CONCLUSIONS Findings revealed that SUA levels were associated with MetS, high TG and high TC. Therefore, it is recommended that clinical attention should be given to symptoms related to elevated SUA - being one of the most important remediable risk factors for MetS - in the annual medical examinations of seafarers.

中文翻译：

---

在油轮上工作的海员中血清尿酸与心血管代谢危险因素和代谢综合征的关联。

背景技术关于代谢综合征（MetS）和血清尿酸（SUA）水平之间的关联的临床解释仍存在争议。因此，本研究的目的是调查在油轮上工作的海员中SUA水平与MetS和其他心脏代谢危险因素（CMRF）的关系。方法这项横断面研究于2015年进行，包括234名在油轮上工作的男性海员。根据SUA的三分位数将参与者分为三组。国家肥胖委员会的报告被用来定义大都会。通过Logistic回归分析评估了SUA，CMRF和MetS之间的关系，并根据年龄，教育水平，工作经历，轮班工作，吸烟和BMI进行了调整。结果受试者年龄36.0±10.3岁（平均±SD）。随着SUA的三分位数增加，平均体重，体重指数（BMI），甘油三酸酯（TG），总胆固醇（TC），低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）出现了明显的上升趋势（P <0.001）。在所有logistic回归分析模型中，SUA第三三分位数参与者的高TG的比值比（OR）比SUA第一三分位数参与者的高TG的比值比（P <0.001）高四倍。高TC的胜算率和SUA水平升高，因此第二三位数参与者的高TC的胜算率为2.47（95％CI：1.10-5.53）（P <0.05）。第一三分。MetS与SUA水平之间存在显着的相关性；6.10（95％CI：1.77-20.94）（P <0.05）。结论研究发现，SUA水平与MetS，高TG和高TC有关。因此，建议在年度海员体检中，应对与SUA升高相关的症状给予临床关注，SUA升高是MetS的最重要可补救风险因素之一。