Optimizing Anisotropic Polyurethane Scaffolds to Mechanically Match with Native Myocardium,ACS Biomaterials Science & Engineering

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Optimizing Anisotropic Polyurethane Scaffolds to Mechanically Match with Native Myocardium
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2020-04-06 , DOI: 10.1021/acsbiomaterials.9b01860
Cancan Xu _{1,

2} , Chuka Okpokwasili _{1,

2} , Yihui Huang _{1,

2} , Xiaodan Shi _{1,

2} , Jinglei Wu _{1,

2} , Jun Liao _{1,

2} , Liping Tang _{1,

2} , Yi Hong _{1,

2}

Affiliation

The biodegradable cardiac patch is desirable to possess mechanical properties mimicking native myocardium for heart infarction treatment. We fabricated a series of anisotropic and biodegradable polyurethane porous scaffolds via thermally induced phase separation (TIPS) and tailored their mechanical properties by using various polyurethanes with different soft segments and varying polymer concentrations. The uniaxial mechanical properties, suture retention strength, ball-burst strength, and biaxial mechanical properties of the anisotropic porous scaffolds were optimized to mechanically match native myocardium. The optimal anisotropic scaffold had a ball burst strength (20.7 ± 1.5 N) comparable to that of native porcine myocardium (20.4 ± 6.0 N) and showed anisotropic behavior close to biaxial stretching behavior of the native porcine myocardium. Furthermore, the optimized porous scaffold was combined with a porcine myocardium-derived hydrogel to form a biohybrid scaffold. The biohybrid scaffold showed morphologies similar to the decellularized porcine myocardial matrix. This combination did not affect the mechanical properties of the synthetic scaffold alone. After in vivo rat subcutaneous implantation, the biohybrid scaffolds showed minimal immune response and exhibited higher cell penetration than the polyurethane scaffold alone. This biohybrid scaffold with biomimetic mechanics and good tissue compatibility would have great potential to be applied as a biodegradable acellular cardiac patch for myocardial infarction treatment.

中文翻译：

优化各向异性聚氨酯支架以与天然心肌机械匹配

可生物降解的心脏补片需要具有模仿天然心肌的机械特性，用于治疗心肌梗塞。我们通过热致相分离（TIPS）制造了一系列各向异性和可生物降解的聚氨酯多孔支架，并通过使用具有不同软链段和不同聚合物浓度的各种聚氨酯来定制其机械性能。各向异性多孔支架的单轴机械性能、缝线保留强度、球爆裂强度和双轴机械性能经过优化，以在机械上匹配天然心肌。最佳各向异性支架的球破裂强度（20.7±1.5N）与天然猪心肌（20.4±6.0N）相当，并且表现出接近天然猪心肌双轴拉伸行为的各向异性行为。此外，优化的多孔支架与猪心肌源性水凝胶结合形成生物混合支架。生物混合支架表现出与脱细胞猪心肌基质相似的形态。这种组合并不影响单独的合成支架的机械性能。在大鼠体内皮下植入后，生物混合支架表现出最小的免疫反应，并且比单独的聚氨酯支架表现出更高的细胞渗透性。这种具有仿生力学和良好组织相容性的生物混合支架将具有作为可生物降解的无细胞心脏补片用于心肌梗死治疗的巨大潜力。

更新日期：2020-04-06

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