Naturally occurring tumor in animals receiving high minerals from deep oceans (DOM: hardness 600 mg/L) from 6 months of age until natural death was firstly assessed in 200 Sprague Dawley rats, randomized into four groups: Control (C), DOM (D), Fructose (F), and Fructose + DOM (FD). Fructose drink contained 11% fructose. Tumor incidence (necropsy at death) in the D group was ~40% lower than that in the C group (P  < .05), together with lower body mass gain and greater locomotive activity during their initial 18 months (P  < .05) but not during later life. X‐ray image analysis on abnormal solid tissue among survivors at 18 and 24 months of age confirms a similar trend, exhibiting ~50% and ~65% lower tumor incidence than the C and F groups, respectively. Reduced‐to‐oxidized glutathione ratio (GSH/GSSG) declined with age for the first three quarters of life on all groups (P  < .05), followed by a resurgence during end‐life among survivors at 24 months. This resurgence is markedly associated with lower tumor expansion but unrelated with DOM supplementation. Our results demonstrate valuable application of minerals and trace elements from deep oceans, as a vastly available natural source, on tumor suppression during normal aging.

中文翻译：

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在接受终生深海矿物质的大鼠中降低了肿瘤的发生而没有延长寿命。

首先在200只Sprague Dawley大鼠中评估了从6个月大时开始到深海接受高矿物质（DOM：硬度600 mg / L）的动物中自然发生的肿瘤，随机分为四组：对照组（C），DOM（D ），果糖（F）和果糖+ DOM（FD）。果糖饮料中含有11％的果糖。D组的肿瘤发生率（死亡时的尸检）比C组低约40％（P  <.05），并且在开始的18个月中体重增加较小，机车活动增加（P <.05），但在以后的生活中则不会。对18和24个月大的幸存者中的异常实体组织进行X射线图像分析证实了类似的趋势，其肿瘤发生率分别比C和F组低约50％和〜65％。所有组生命的前四分之三的氧化谷胱甘肽比值（GSH / GSSG）均随着年龄的增长而下降（P  <.05），随后存活者在24个月的终末期复活。这种复发明显与较低的肿瘤扩张有关，但与补充DOM无关。我们的结果表明，深海矿物质和微量元素作为一种广泛可用的天然资源，在正常衰老过程中对肿瘤抑制具有重要的应用价值。