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Atomic Force Microscopy in Mechanoimmunology Analysis: A New Perspective for Cancer Immunotherapy.
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-04-02 , DOI: 10.1002/biot.201900559 Natalia Kristi 1 , Alidha Gafur 1 , Lingwen Kong 2 , Xinshuang Ma 1 , Zhiyi Ye 1 , Guixue Wang 1
Biotechnology Journal ( IF 3.2 ) Pub Date : 2020-04-02 , DOI: 10.1002/biot.201900559 Natalia Kristi 1 , Alidha Gafur 1 , Lingwen Kong 2 , Xinshuang Ma 1 , Zhiyi Ye 1 , Guixue Wang 1
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Immunotherapy has remarkable success outcomes against hematological malignancies with high rates of complete remission. To date, many studies have been conducted to increase its effectiveness in other types of cancer. However, it still yields unsatisfying results in solid tumor therapy. This limitation is partly attributed to the lack of understanding of how immunotherapy works in cancer from other perspectives. The traditional studies focus on the biological and chemical perspectives to determine which molecular substrates are involved in the immune system that can eradicate cancer cells. In the last decades, accumulating evidence has shown that physical properties also play important roles in the immune system to combat cancer, which is studied in mechanoimmunology. Mechanoimmunology analysis requires special tools; and herein, atomic force microscopy (AFM) appears as a versatile tool to determine and quantify the mechanical properties of a sample in nanometer precisions. Owing to its multifunctional capabilities, AFM can be used to explore immune system function from the physical perspective. This review paper explains the mechanoimmunology of how immune systems work through AFM, which includes mechanosignaling, mechanosensing, and mechanotransduction, with the aim to deepen the understanding of the mechanistic role of immunotherapy for further development in cancer treatment.
中文翻译：
机械免疫学分析中的原子力显微镜：癌症免疫治疗的新视角。
免疫疗法对血液系统恶性肿瘤具有显着的成功结果，完全缓解率很高。迄今为止，已经进行了许多研究来提高其在其他类型癌症中的有效性。但是，它在实体瘤治疗中仍然不能令人满意。该局限性部分归因于从其他角度缺乏对免疫疗法如何在癌症中发挥作用的理解。传统研究侧重于生物学和化学观点，以确定哪些分子底物参与可以消灭癌细胞的免疫系统。在过去的几十年中，越来越多的证据表明，物理性质在免疫系统中也具有重要作用，可以抵抗癌症，这在机械免疫学中得到了研究。机械免疫分析需要特殊的工具；在这里，原子力显微镜（AFM）似乎是一种通用工具，可以以纳米精度确定和量化样品的机械性能。由于其多功能功能，AFM可用于从物理角度探索免疫系统功能。这篇综述论文解释了免疫系统如何通过AFM起作用的机械免疫学，包括机械信号传递，机械传感和机械转导，旨在加深对免疫疗法在癌症治疗中进一步发展的机械作用的理解。
更新日期：2020-04-02
中文翻译：
机械免疫学分析中的原子力显微镜：癌症免疫治疗的新视角。
免疫疗法对血液系统恶性肿瘤具有显着的成功结果，完全缓解率很高。迄今为止，已经进行了许多研究来提高其在其他类型癌症中的有效性。但是，它在实体瘤治疗中仍然不能令人满意。该局限性部分归因于从其他角度缺乏对免疫疗法如何在癌症中发挥作用的理解。传统研究侧重于生物学和化学观点，以确定哪些分子底物参与可以消灭癌细胞的免疫系统。在过去的几十年中，越来越多的证据表明，物理性质在免疫系统中也具有重要作用，可以抵抗癌症，这在机械免疫学中得到了研究。机械免疫分析需要特殊的工具；在这里，原子力显微镜（AFM）似乎是一种通用工具，可以以纳米精度确定和量化样品的机械性能。由于其多功能功能，AFM可用于从物理角度探索免疫系统功能。这篇综述论文解释了免疫系统如何通过AFM起作用的机械免疫学，包括机械信号传递，机械传感和机械转导，旨在加深对免疫疗法在癌症治疗中进一步发展的机械作用的理解。
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