Left prefrontal impact links subthalamic stimulation with depressive symptoms,Annals of Neurology

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Left prefrontal impact links subthalamic stimulation with depressive symptoms
Annals of Neurology ( IF 8.1 ) Pub Date : 2020-04-30 , DOI: 10.1002/ana.25734
Friederike Irmen _{1,

2,

3} , Andreas Horn ₁ , Philip Mosley _{4,

5} , Alistair Perry _{6,

7} , Jan Niklas Petry-Schmelzer ₈ , Haidar S Dafsari ₈ , Michael Barbe ₈ , Veerle Visser-Vandewalle ₉ , Gerd-Helge Schneider ₁₀ , Ningfei Li ₁ , Dorothee Kübler ₁ , Gregor Wenzel ₁ , Andrea A Kühn _{1,

2,

11}

Affiliation

Department of Neurology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany.
Department of Biological Psychology and Cognitive Neuroscience, Freie Universität Berlin, Berlin, Germany.
Systems Neuroscience Group, QIMR Berghofer Medical Research Institute, Herston, Australia.
Queensland Brain Institute, University of Queensland, St. Lucia, Australia.
Max Planck UCL Centre for Computational Psychiatry and Ageing Research, Max Planck Institute for Human Development, Berlin, Germany.
Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany.
Faculty of Medicine and University Hospital Cologne, Department of Neurology, University of Cologne, Cologne, Germany.
Department of Stereotactic and Functional Neurosurgery, University Hospital Cologne, Cologne, Germany.
Department of Neurosurgery, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Deutsches Zentrum für Neurodegenerative Erkrankungen, Berlin, Germany.

Subthalamic nucleus deep brain stimulation (STN‐DBS) in Parkinson's disease (PD) not only stimulates focal target structures but also affects distributed brain networks. The impact this network modulation has on non‐motor DBS effects is not well‐characterized. By focusing on the affective domain, we systematically investigate the impact of electrode placement and associated structural connectivity on changes in depressive symptoms following STN‐DBS, which have been reported to improve, worsen, or remain unchanged.

中文翻译：

左前额叶撞击将丘脑下刺激与抑郁症状联系起来

帕金森病 (PD) 中的丘脑底核深部脑刺激 (STN-DBS) 不仅会刺激局灶性目标结构，还会影响分布式脑网络。这种网络调制对非运动 DBS 效应的影响尚未得到很好的表征。通过关注情感领域，我们系统地研究了电极放置和相关结构连接对 STN-DBS 后抑郁症状变化的影响，据报道这些变化会改善、恶化或保持不变。

更新日期：2020-04-30

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