Medaka (O. latipes) and zebrafish (D. rerio) are two teleost fish increasingly used as models to study human skeletal diseases. Although they are similar in size, swimming pattern and many other characteristics, these two species are very distant from an evolutionary point of view (by at least 100 million years). A prominent difference between the skeletons of medaka and zebrafish is the total absence of osteocytes in medaka (anosteocytic), while zebrafish bone contains numerous osteocytes (osteocytic). This fundamental difference suggests the possibility that the bony elements of their skeleton may be different in a variety of other aspects, structural, mechanical or both, particularly in heavily loaded bones like the vertebrae. Here we report on the results of a comparative study aimed to determine the similarities and differences in medaka and zebrafish vertebrae, in terms of their macro- to nano-structure, composition and mechanical properties. Our results reveal many similarities between medaka and zebrafish vertebrae, making the lack or presence of osteocytes the only major difference between the bones of these two species.

中文翻译：

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青鳉 (O. latipes ) 和斑马鱼 (D. rerio ) 骨细胞椎骨的结构、组成和力学性能比较

Medaka (O. latipes) 和斑马鱼 (D. rerio) 是两种越来越多地用作研究人类骨骼疾病模型的硬骨鱼。尽管它们在大小、游泳方式和许多其他特征上相似，但从进化的角度来看，这两个物种相距甚远（至少相差 1 亿年）。青鳉和斑马鱼骨骼之间的一个显着区别是青鳉中完全没有骨细胞（去骨细胞），而斑马鱼骨中含有大量的骨细胞（骨细胞）。这种根本差异表明，他们骨骼的骨骼元素可能在结构、机械或两者兼有的其他各个方面有所不同，特别是在像椎骨这样的重负荷骨骼中。在这里，我们报告了一项比较研究的结果，旨在确定青鳉和斑马鱼椎骨在宏观到纳米结构、成分和机械性能方面的异同。我们的结果揭示了青鳉和斑马鱼椎骨之间的许多相似之处，这使得骨细胞的缺乏或存在成为这两个物种骨骼之间唯一的主要区别。