Investigation of Parameters that Affect Resin Swelling in Green Solvents,ChemistryOpen

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Investigation of Parameters that Affect Resin Swelling in Green Solvents
ChemistryOpen ( IF 2.5 ) Pub Date : 2020-04-03 , DOI: 10.1002/open.202000030
Chidi Amadi-Kamalu ₁ , Holly Clarke ₁ , Matthew McRobie ₁ , James Mortimer ₁ , Michael North ₁ , Yanrui Ran ₁ , Anne Routledge ₁ , Dani Sibbald ₁ , Matthew Tickias ₁ , Kai Tse ₁ , Helen Willway ₁

Affiliation

The influence of various physical and chemical factors on the swelling of polystyrene and PEG based resins in greener organic solvents has been systematically investigated. In general, chemical factors: the nature of the functionality/linker and the degree of loading were found to have a far larger influence on the swelling of the resins than physical parameters such as bead size. The results are interpreted in terms of Hansen solubility parameters for the solvents and there is evidence that some solvents interact with the polymeric core of a resin whilst others interact with the functionality. The results are extended to a study of the changes in resin swelling observed during both deprotection and chain elongation reactions during solid phase peptide synthesis.

中文翻译：

影响树脂在绿色溶剂中溶胀的参数研究

系统研究了各种物理和化学因素对聚苯乙烯和聚乙二醇基树脂在绿色有机溶剂中溶胀的影响。一般来说，化学因素：官能团/连接体的性质和负载程度对树脂溶胀的影响比物理参数（例如珠粒尺寸）大得多。结果根据溶剂的汉森溶解度参数进行解释，并且有证据表明一些溶剂与树脂的聚合物核相互作用，而另一些溶剂与官能团相互作用。结果扩展到对固相肽合成过程中脱保护和链延长反应期间观察到的树脂溶胀变化的研究。

更新日期：2020-04-03

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