Cell‐Penetrating Peptides and Polymers for Improved Drug Delivery,ChemNanoMat

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Cell‐Penetrating Peptides and Polymers for Improved Drug Delivery
ChemNanoMat ( IF 2.6 ) Pub Date : 2020-04-20 , DOI: 10.1002/cnma.202000118
Lin Gui ₁ , Xue‐Hao Zhang ₂ , Zeng‐Ying Qiao ₂ , Hao Wang ₂

Affiliation

Effective delivery of biologically active compounds including peptides, proteins, and nucleic acids into cells is an obstacle in the drug research. The intracellular delivery of biological agents generally relies on the endocytosis pathway, causing them to be trapped in endosomes and lysosomes. Cell‐penetrating peptides (CPPs) have previously been shown to be a useful transport tool for delivering many kinds of goods into cells through cell membranes. The latest discovery of cell penetrating poly(disulfide)s (CPDs) with excellent cytosolic delivery efficiency represents a major breakthrough in this field. In this work, we will focus on the latest advances in biological applications of the CPPs and new opportunities opened up by the CPDs.

中文翻译：

细胞穿透肽和聚合物可改善药物递送

有效地将生物活性化合物（包括肽，蛋白质和核酸）输送到细胞中是药物研究的障碍。生物剂的细胞内递送通常依赖于内吞作用途径，导致它们被困在内体和溶酶体中。先前已经证明，细胞穿透肽（CPPs）是一种有用的转运工具，可通过细胞膜将多种货物输送到细胞中。具有优异细胞溶质递送效率的细胞穿透性聚二硫（CPD）的最新发现代表了该领域的重大突破。在这项工作中，我们将专注于CPP的生物学应用的最新进展以及CPD带来的新机遇。

更新日期：2020-04-20

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