Riboflavin Is Directly Involved in N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases.,ChemBioChem

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Riboflavin Is Directly Involved in N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-04-03 , DOI: 10.1002/cbic.202000071
Chengchang Zhang ₁ , Meiling Lu ₁ , Lin Lin ₂ , Zhangjian Huang ₁ , Rongguang Zhang ₂ , Xuri Wu ₁ , Yijun Chen ₁

Affiliation

Direct transfer: Riboflavin directly transfers electrons to bacterial cytochrome P450 monooxygenases in an oxidative N‐dealkylation. A new mechanism for the electron‐transfer process is proposed that could be generally applicable to numerous P450‐like monooxygenases that lack the reductase domain.