A Transparent, Wearable Fluorescent Mouthguard for High-Sensitive Visualization and Accurate Localization of Hidden Dental Lesion Sites.,Advanced Materials

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A Transparent, Wearable Fluorescent Mouthguard for High-Sensitive Visualization and Accurate Localization of Hidden Dental Lesion Sites.
Advanced Materials ( IF 27.4 ) Pub Date : 2020-04-02 , DOI: 10.1002/adma.202000060
Xuemeng Li ₁ , Chongdai Luo _{1,

2} , Quanying Fu ₁ , Cuiping Zhou _{3,

4} , Marina Ruelas ₄ , Yingshuting Wang ₁ , Jinxu He ₁ , Yangyang Wang ₁ , Yu Shrike Zhang ₄ , Jianhua Zhou _{1,

4}

Affiliation

Accurate detection and early diagnosis of oral diseases such as dental caries and periodontitis, can be potentially achieved by detecting the secretion of volatile sulfur compounds (VSCs) in oral cavities. Current diagnostic approaches for VSCs can detect the existence and concentrations, yet are not capable of locating the dental lesion sites. Herein, the development of a unique approach for accurately locating dental lesion sites using a fluorescent mouthguard consisting of the zinc oxide-poly(dimethylsiloxane) (ZnO-PDMS) nanocomposite to detect the local release of VSCs is reported. The ZnO-PDMS mouthguard displays a highly sensitive and selective response to VSCs, and exhibits high fluorescent stability, good biocompatibility, and low biological toxicity in normal physiological environments. Then, the wearable ZnO-PDMS mouthguard is demonstrated to be able to identify the precise locations of lesion sites in human subjects. Combined with image analysis, the mouthguards successfully uncover the precise locations of dental caries, allowing convenient screening of hidden dental lesion sites that are oftentimes omitted by dentists. Due to low cost, long-term stability, and good patient compliance, the proposed wearable mouthguard is suitable for large-scale production and enables widely applicable, preliminary yet accurate screening of dental lesions prior to dental clinics and routine physical examinations.

中文翻译：

透明，可佩戴的荧光灯护齿罩，可对隐藏的牙科病变部位进行高灵敏度的可视化和精确定位。

通过检测口腔中挥发性硫化合物（VSC）的分泌，可以潜在地实现对口腔疾病（如龋齿和牙周炎）的准确检测和早期诊断。VSCs的当前诊断方法可以检测其存在和浓度，但无法定位牙齿病变部位。本文中，已报道了一种独特的方法的开发，该方法可使用由氧化锌-聚（二甲基硅氧烷）（ZnO-PDMS）纳米复合材料组成的荧光护口器精确定位牙齿病变部位，以检测VSC的局部释放。ZnO-PDMS护齿对VSC表现出高度敏感和选择性的反应，并且在正常的生理环境中具有较高的荧光稳定性，良好的生物相容性和较低的生物毒性。然后，事实证明，可穿戴的ZnO-PDMS护口罩能够识别人类受试者病变部位的精确位置。结合图像分析，护齿器成功地发现了龋齿的精确位置，从而可以方便地筛查隐藏的病变部位，而这些部位通常是牙医所忽略的。由于成本低，长期稳定性好以及患者依从性好，因此建议的可穿戴式护齿罩适用于大规模生产，并能够在牙科诊所和常规体检之前对牙齿病变进行广泛适用的，初步而准确的筛查。可以方便地筛查隐藏的牙齿病变部位，而牙医通常会忽略这些部位。由于成本低，长期稳定性好以及患者依从性好，因此建议的可穿戴式护齿罩适用于大规模生产，并能够在牙科诊所和常规体检之前对牙齿病变进行广泛适用的，初步而准确的筛查。可以方便地筛查隐藏的牙齿病变部位，而牙医通常会忽略这些部位。由于成本低，长期稳定性好以及患者依从性好，因此建议的可穿戴式护齿罩适用于大规模生产，并能够在牙科诊所和常规体检之前对牙齿病变进行广泛适用的，初步而准确的筛查。

更新日期：2020-04-02

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