Abstract By using the mixed-ligand approach, a Cu(II)-based metal-organic framework (MOF), {[Me2NH2][Cu2(BDPP)(im)]·4DMF}n (1) (H4BDPP = 3,5-bis(3,5-dicarboxylphenyl)pyridine, Him = imidazole), has been prepared via solvothermal reaction of Cu(NO3)2·3H2O, H4BDPP and Him in a mixed solvent of DMF and water. Due to its high solvent accessible void (58%) and suitable pore size, activated complex 1a demonstrates a moderate CO2 sorption capacity and a high CO2/N2 sorption selectivity around room temperature. In the pharmacological activity evaluation, the blood pressure was measured once a day until the 20th day, the vascular endothelial cells in the rats were collected, and the TNF-α and VACM-1 expression level was detected by western blot. The results obtained from molecular docking and pose scoring software exhibited a possible binding mode of the compound binding to NF-κB, which might provide potential regulation mechanisms for the compound. Graphical Abstract

中文翻译：

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通过降低血管内皮细胞中 TNF-α 和 VACM-1 的表达，Cu(II)-有机框架用于选择性 CO2/N2 分离和对妊娠高血压疾病的保护作用

摘要 通过使用混合配体方法，一种基于 Cu(II) 的金属有机骨架 (MOF)，{[Me2NH2][Cu2(BDPP)(im)]·4DMF}n (1) (H4BDPP = 3,5 -双（3,5-二羧基苯基）吡啶，Him = 咪唑），是通过 Cu(NO3)2·3H2O、H4BDPP 和 Him 在 DMF 和水的混合溶剂中的溶剂热反应制备的。由于其高溶剂可及空隙率 (58%) 和合适的孔径，活化复合物 1a 表现出中等的 CO2 吸附能力和室温附近的高 CO2/N2 吸附选择性。在药理活性评价中，每天测量一次血压，直至第20天，收集大鼠血管内皮细胞，Western blot检测TNF-α和VACM-1的表达水平。从分子对接和位姿评分软件获得的结果展示了化合物与 NF-κB 结合的可能结合模式，这可能为化合物提供潜在的调控机制。图形概要